Oksenhendler E, Lida H, D'Agay M F, Morinet F, Pulik M, Davi F, Clauvel J P
Department of Hematology, St Louis Hospital, Paris, France.
Arch Intern Med. 1989 Oct;149(10):2359-61.
Two patients presented with a large tumoral nasopharyngeal lesion with obstructive symptoms, which suggested a malignant tumor. They were black men of Caribbean origin who were infected with human immunodeficiency virus 1. In both cases, histologic examination revealed intense but benign lymphoid follicular hyperplasia, and immunohistochemical studies were consistent with its polyclonal nature. DNA studies performed on tumoral tissue failed to disclose immunoglobulin or T-cell receptor gene rearrangements. In one biopsy specimen, DNA hybridization using Epstein-Barr virus-specific probes showed no evidence of Epstein-Barr virus-DNA sequences. The nasopharynx can be involved in the diffuse extranodal lymphoid hyperplasia associated with human immunodeficiency virus infection.
两名患者出现鼻咽部巨大肿瘤性病变并伴有阻塞症状，提示为恶性肿瘤。他们是来自加勒比地区的黑人男性，感染了人类免疫缺陷病毒1型。在这两个病例中，组织学检查显示为强烈但良性的淋巴滤泡增生，免疫组化研究与其多克隆性质一致。对肿瘤组织进行的DNA研究未能发现免疫球蛋白或T细胞受体基因重排。在一份活检标本中，使用爱泼斯坦-巴尔病毒特异性探针进行的DNA杂交未显示有爱泼斯坦-巴尔病毒DNA序列的证据。鼻咽部可累及与人类免疫缺陷病毒感染相关的弥漫性结外淋巴组织增生。
