韩国克兰费尔特综合征男性患者的肥胖与高血糖：韩国内分泌学会登记研究
Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry.
作者信息
Han Seung Jin, Kim Kyung Soo, Kim Wonjin, Kim Jung Hee, Lee Yong Ho, Nam Ji Sun, Seo Ji A, Kim Bu Kyung, Lee Jihyun, Chung Jin Ook, Kim Min Hee, Sohn Tae Seo, Choi Han Seok, Hong Seong Bin, Chung Yoon Sok
机构信息
Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea.
Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
出版信息
Endocrinol Metab (Seoul). 2016 Dec;31(4):598-603. doi: 10.3803/EnM.2016.31.4.598.
BACKGROUND
The aim of this study was to investigate the prevalence of obesity in Korean men with Klinefelter syndrome (KS) and the associated risk factors for obesity and hyperglycemia.
METHODS
Data were collected retrospectively from medical records from 11 university hospitals in Korea between 1994 and 2014. Subjects aged ≥18 years with newly diagnosed KS were enrolled. The following parameters were recorded at baseline before treatment: chief complaint, height, weight, fasting glucose level, lipid panel, blood pressure, testosterone, luteinizing hormone, follicle-stimulating hormone, karyotyping patterns, and history of hypertension, diabetes, and dyslipidemia.
RESULTS
Data were analyzed from 376 of 544 initially enrolled patients. The rate of the 47 XXY chromosomal pattern was 94.1%. The prevalence of obesity (body mass index ≥25 kg/m²) in Korean men with KS was 42.6%. The testosterone level was an independent risk factor for obesity and hyperglycemia.
CONCLUSION
Obesity is common in Korean men with KS. Hypogonadism in patients with KS was associated with obesity and hyperglycemia.
背景
本研究旨在调查患有克兰费尔特综合征（KS）的韩国男性肥胖症的患病率以及肥胖和高血糖的相关危险因素。
方法
回顾性收集1994年至2014年期间韩国11家大学医院的病历数据。纳入年龄≥18岁且新诊断为KS的受试者。在治疗前的基线记录以下参数：主要症状、身高、体重、空腹血糖水平、血脂谱、血压、睾酮、促黄体生成素、促卵泡生成素、核型模式以及高血压、糖尿病和血脂异常病史。
结果
对最初纳入的544例患者中的376例进行了数据分析。47 XXY核型模式的发生率为94.1%。患有KS的韩国男性肥胖症（体重指数≥25 kg/m²）的患病率为42.6%。睾酮水平是肥胖和高血糖的独立危险因素。
结论
肥胖在患有KS的韩国男性中很常见。KS患者的性腺功能减退与肥胖和高血糖有关。
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