Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Diabetes Metab J. 2013 Dec;37(6):433-49. doi: 10.4093/dmj.2013.37.6.433. Epub 2013 Dec 12.
Dyslipidemia is a major risk factor of cardiovascular disease. The aim of this study was to investigate the changing trends in the prevalence and management status of dyslipidemia among Korean adults.
The prevalence of dyslipidemia and the rates of awareness, treatment, and control of dyslipidemia were investigated in adults aged ≥20 years from the Korea National Health and Nutrition Surveys (KNHANES) 1998 to 2010. The updated National Cholesterol Education Program criteria was used, which define dyslipidemia as having one or more of the following lipid abnormalities: hypercholesterolemia (total cholesterol ≥240 mg/dL or diagnosis of dyslipidemia or use of lipid-lowering drugs), hypertriglyceridemia (≥150 mg/dL), hyper-low density lipoprotein (LDL) cholesterolemia (≥160 mg/dL or diagnosis of dyslipidemia or use of lipid-lowering drugs), and hypo-high density lipoprotein (HDL)-cholesterolemia (<40 mg/dL in men and <50 mg/dL in women).
The number of participants was 6,921, 4,894, 5,312, 2,733, 6,295, 6,900, and 5,738 in KNHANES 1998, 2001, 2005, 2007, 2008, 2009, and 2010, respectively. Age-standardized prevalence rates of dyslipidemia were 54.0%, 65.8%, 66.5%, 60.6%, 58.7%, 58.9%, and 59.0% in 1998, 2001, 2005, 2007, 2008, 2009, and 2010, respectively. Hypertriglyceridemia and hypo-HDL-cholesterolemia were the two most frequent lipid abnormalities. The overall prevalence of hypercholesterolemia and hyper-LDL-cholesterolemia increased by 1.36- and 1.35-fold in 2010 compared with 2007, respectively. Awareness, treatment, and control rates of dyslipidemia improved over the period of surveys in both sexes. In 2010, about 30% of dyslipidemic patients who received lipid-lowering treatment reached target levels.
Although the management status of dyslipidemia has improved during recent years, effective strategy is required for achieving better prevention, treatment, and control of dyslipidemia.
血脂异常是心血管疾病的主要危险因素。本研究旨在探讨韩国成年人血脂异常的患病率和管理现状的变化趋势。
采用韩国国家健康和营养调查（KNHANES）1998 年至 2010 年≥20 岁成年人的血脂异常患病率以及知晓率、治疗率和控制率进行调查。采用更新的国家胆固醇教育计划标准，将血脂异常定义为以下一种或多种脂质异常：高胆固醇血症（总胆固醇≥240mg/dL 或诊断为血脂异常或使用降脂药物）、高甘油三酯血症（≥150mg/dL）、低高密度脂蛋白（LDL）胆固醇血症（≥160mg/dL 或诊断为血脂异常或使用降脂药物）和低高密度脂蛋白（HDL）胆固醇血症（男性<40mg/dL，女性<50mg/dL）。
KNHANES 1998 年、2001 年、2005 年、2007 年、2008 年、2009 年和 2010 年的参与者人数分别为 6921、4894、5312、2733、6295、6900 和 5738 人。1998 年、2001 年、2005 年、2007 年、2008 年、2009 年和 2010 年，血脂异常的年龄标准化患病率分别为 54.0%、65.8%、66.5%、60.6%、58.7%、58.9%和 59.0%。高甘油三酯血症和低 HDL-胆固醇血症是最常见的两种脂质异常。与 2007 年相比，2010 年高胆固醇血症和高 LDL-胆固醇血症的总患病率分别增加了 1.36 倍和 1.35 倍。在男女两性中，血脂异常的知晓率、治疗率和控制率在调查期间均有所改善。2010 年，约 30%接受降脂治疗的血脂异常患者达到了目标水平。
尽管近年来血脂异常的管理状况有所改善，但仍需要采取有效的策略，以更好地预防、治疗和控制血脂异常。
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