Klochkov S A, Vtiurin B V, Seniakovich V M
Arkh Patol. 1989;51(6):43-8.
Histological and electron microscopic examinations were made of hepatic biopsies from children in various types of congenital fibrosis of the liver (CFL). A relationship was found between clinico-laboratory evidence of liver dysfunction and severity of ultrastructural changes in hepatic parenchyma in non-complicated and complicated CFL. Signs of active intralobular fibrosis were revealed in cases of complicated CFL. Perisinusoid and perihepatocellular depositions of collagenous fibers lead to isolation of hepatic cells from the blood supply system, which is a cause of dystrophic changes in the liver and affects the function of the organ.
对患有各种类型先天性肝纤维化（CFL）的儿童肝脏活检组织进行了组织学和电子显微镜检查。在非复杂性和复杂性CFL中，发现肝功能障碍的临床实验室证据与肝实质超微结构变化的严重程度之间存在关联。在复杂性CFL病例中发现了小叶内活动性纤维化的迹象。窦周和肝细胞周围胶原纤维沉积导致肝细胞与血液供应系统隔离，这是肝脏营养不良性变化的原因，并影响器官功能。
