[Analysis of ultrastructural changes of the liver in children with congenital liver fibrosis].

Histological and electron microscopic examinations were made of hepatic biopsies from children in various types of congenital fibrosis of the liver (CFL). A relationship was found between clinico-laboratory evidence of liver dysfunction and severity of ultrastructural changes in hepatic parenchyma in non-complicated and complicated CFL. Signs of active intralobular fibrosis were revealed in cases of complicated CFL. Perisinusoid and perihepatocellular depositions of collagenous fibers lead to isolation of hepatic cells from the blood supply system, which is a cause of dystrophic changes in the liver and affects the function of the organ.