Scordo Kristine, Pickett Kim Anne
Kristine Scordo is professor and director of the adult-gerontology acute care NP program in the College of Nursing at Wright State University in Dayton, OH. Kim Anne Pickett is a family NP at Spartanburg Regional Healthcare System in Spartanburg, SC. Contact author: Kristine Scordo,
Am J Nurs. 2017 Jan;117(1):24-31. doi: 10.1097/01.NAJ.0000511539.37103.0b.
: Since the introduction of HMG-CoA reductase inhibitors, also known as statins, as an adjunct to diet in the treatment of hyperlipidemia and the greater emphasis placed on reducing low-density lipoprotein (LDL) cholesterol levels in the prevention of atherosclerosis and cardiovascular disease (CVD), there has been less focus on the value of lowering serum triglyceride levels. Many patients are aware of their "good" and "bad" cholesterol levels, but they may not be aware of their triglyceride level or of the association between high triglycerides and the development of CVD. In recent years, however, in light of the increasing incidences of obesity, insulin resistance, and type 2 diabetes, lowering triglyceride levels has gained renewed interest. In addition to the focus on lowering LDL cholesterol levels in CVD prevention, clinicians need to be aware of the role of triglycerides-their contribution to CVD, and the causes and treatment of hypertriglyceridemia.
自从引入3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂（也称为他汀类药物）作为饮食辅助手段用于治疗高脂血症，并且在预防动脉粥样硬化和心血管疾病（CVD）方面更加注重降低低密度脂蛋白（LDL）胆固醇水平以来，对降低血清甘油三酯水平的价值的关注就减少了。许多患者知道自己的“好”胆固醇和“坏”胆固醇水平，但他们可能不知道自己的甘油三酯水平，也不知道高甘油三酯与CVD发生之间的关联。然而，近年来，鉴于肥胖、胰岛素抵抗和2型糖尿病的发病率不断上升，降低甘油三酯水平重新引起了人们的兴趣。除了在CVD预防中注重降低LDL胆固醇水平外，临床医生还需要了解甘油三酯的作用——它们对CVD的影响，以及高甘油三酯血症的病因和治疗方法。
