小儿肠外营养相关肝病
Pediatric Parenteral Nutrition-Associated Liver Disease.
作者信息
Israelite Jill C
机构信息
Massachusetts General Hospital, Boston, Massachusetts. Jill C. Israelite, RD, LDN, CNSC®, CSP, has been in practice as an inpatient clinical nutrition specialist at Massachusetts General Hospital since 2005. She is board certified as a clinical nutrition support clinician and specialist in pediatric nutrition. Jill specializes in nutrition support, providing enteral and parenteral recommendations to the medical team for FTT, metabolic, short gut, trauma, CF and other patients in the pediatric intensive care unit and pediatric floors of MassGeneral Hospital for Children.
出版信息
J Infus Nurs. 2017 Jan/Feb;40(1):51-54. doi: 10.1097/NAN.0000000000000206.
Pediatric parenteral nutrition-associated liver disease (PNALD) is typically defined as a decrease in bile flow that is independent of a mechanical obstruction and of any other underlying liver disease. It is most often seen in pediatric patients receiving parenteral nutrition support. Up to 50% to 66% of children receiving long-term parenteral nutrition are reported to be diagnosed with PNALD. The goal of treatment for PNALD is advancement to full enteral nutrition and elimination of dependence on parenteral nutrition support. Achieving this goal is not always possible, especially in patients with short bowel syndrome. The following review article highlights some of the current treatment strategies focused on prevention or correction of PNALD as noted in current American Society for Parenteral and Enteral Nutrition guidelines.
小儿肠外营养相关肝病（PNALD）通常定义为胆汁流量减少，且与机械性梗阻及任何其他潜在肝病无关。它最常见于接受肠外营养支持的儿科患者。据报道，接受长期肠外营养的儿童中，高达50%至66%被诊断为PNALD。PNALD的治疗目标是逐步过渡到完全肠内营养并消除对肠外营养支持的依赖。实现这一目标并非总是可行，尤其是在短肠综合征患者中。以下综述文章重点介绍了当前美国肠外和肠内营养学会指南中提到的一些针对PNALD预防或纠正的当前治疗策略。
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