Huang C C, Chu N S, Lu C S, Wang J D, Tsai J L, Tzeng J L, Wolters E C, Calne D B
Department of Neurology, Chang Gung Medical College Hospital, Taipei, Taiwan, Republic of China.
Arch Neurol. 1989 Oct;46(10):1104-6. doi: 10.1001/archneur.1989.00520460090018.
We report six cases of chronic manganese intoxication in workers at a ferromanganese factory in Taiwan. Diagnosis was confirmed by assessing increased manganese concentrations in the blood, scalp, and pubic hair. In addition, increased manganese levels in the environmental air were established. The patients showed a bradykinetic-rigid syndrome indistinguishable from Parkinson's disease that responded to treatment with levodopa.
我们报告了台湾一家锰铁工厂工人中6例慢性锰中毒的病例。通过评估血液、头皮和阴毛中锰浓度升高来确诊。此外，还确定了环境空气中锰水平升高。患者表现出一种与帕金森病难以区分的运动迟缓-强直综合征，对左旋多巴治疗有反应。
