Soares Ana Thalita Gonçalves, Silva Aline de Castro, Tinkov Alexey A, Khan Haroon, Santamaría Abel, Skalnaya Margarita G, Skalny Anatoly V, Tsatsakis Aristidis, Bowman Aaron B, Aschner Michael, Ávila Daiana Silva
Laboratory of Biochemistry and Toxicology in Caenorhabditis elegans, Graduation Program in Biochemistry, Federal University of Pampa Campus Uruguaiana, RS, Brazil.
Yaroslavl State University, Yaroslavl, Russia; IM Sechenov First Moscow State Medical University, Moscow, Russia; Federal Scientific Center of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 460000 Orenburg, Russia.
J Trace Elem Med Biol. 2020 Sep;61:126554. doi: 10.1016/j.jtemb.2020.126554. Epub 2020 May 20.
Manganese (Mn) is a metal ubiquitously present in nature and essential for many living organisms. As a trace element, it is required in small amounts for the proper functioning of several important enzymes, and reports of Mn deficiency are indeed rare.
This mini-review will cover aspects of Mn toxicokinetics and its impact on brain neurotransmission, as well as its Janus-faced effects on humans and other animal's health.
The estimated safe upper limit of intracellular Mn for physiological function is in anarrow range of 20-53 μM.Therefore, intake of higher levels of Mn and the outcomes, especially to the nervous system, have been well documented.
The metal affects mostly the brain by accumulating in specific areas, altering cognitive functions and locomotion, thus severely impacting the health of the exposed organisms.
锰（Mn）是一种在自然界中普遍存在的金属，对许多生物来说必不可少。作为一种微量元素，几种重要酶的正常功能只需少量锰，锰缺乏的报告确实很少见。
本小型综述将涵盖锰的毒代动力学方面及其对大脑神经传递的影响，以及其对人类和其他动物健康的双面效应。
生理功能所需的细胞内锰的估计安全上限在20 - 53 μM的狭窄范围内。因此，摄入较高水平的锰及其后果，尤其是对神经系统的影响，已有充分记录。
这种金属主要通过在特定区域蓄积、改变认知功能和运动能力来影响大脑，从而严重影响受暴露生物的健康。
