Abd-Elhafeez Hanan H, Soliman Soha A
Department of Anatomy and Histology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
Cells Tissues Organs. 2017;203(5):295-315. doi: 10.1159/000452243. Epub 2016 Dec 29.
Telocytes are a special type of interstitial cells characterized by distinctive cellular extensions with alternating thin segments (podomers) and dilations (podoms). Telocytes establish contact with various cells and structures, but their role in the regulation of the function of many cell types is still obscure. The aim of the current study was to investigate the morphology, histochemistry, and immunohistochemistry of telocytes, and their distribution, organization, and morphometric measurements in different layers of the adult bovine uterine tube. Telocytes showed positive immunostaining for CD117, S-100 protein, vimentin, desmin, α-smooth muscle actin, tubulin, laminin, estrogen receptor-α, and progesterone receptor. They were organized in different types of sheaths: subepithelial, inner/outer perimuscular, and intramuscular sheaths. Telocytes were scattered in the lamina propria, in the muscular layer, and the serosa. According to their size, they were grouped into different types of telocytes: small, large, and giant telocytes. Small telocytes were the most common type and located in all layers; large telocytes were observed in the epithelium, lamina propria, and inner/outer perimuscular and intramuscular sheaths, and giant telocytes were found in the external layer of the outer perimuscular sheath. Telocytes were connected by thin and thick telopodes (fenestrated membranes). Fenestrated membranes enabled connections between telocytes along the entire muscular wall of the uterine tube. Telocytes established an extensive biological network of different types of cells and structures, including epithelial, muscular, and mast cells, blood vessels, glomus, and nerve fibers. We hypothesize that telocytes help to organize the functional coordination between different types of cells in the uterine tube.
端细胞是一种特殊类型的间质细胞，其特征在于具有独特的细胞延伸，这些延伸具有交替的细段（podomers）和扩张部分（podoms）。端细胞与各种细胞和结构建立联系，但其在多种细胞类型功能调节中的作用仍不清楚。本研究的目的是调查成年牛输卵管不同层中端细胞的形态学、组织化学和免疫组织化学，以及它们的分布、组织和形态测量。端细胞对CD117、S-100蛋白、波形蛋白、结蛋白、α-平滑肌肌动蛋白、微管蛋白、层粘连蛋白、雌激素受体-α和孕激素受体呈阳性免疫染色。它们以不同类型的鞘组织存在：上皮下鞘、肌层内/外鞘和肌内鞘。端细胞散布在固有层、肌层和浆膜中。根据其大小，它们被分为不同类型的端细胞：小端细胞、大端细胞和巨大端细胞。小端细胞是最常见的类型，存在于所有层中；大端细胞见于上皮、固有层、肌层内/外鞘和肌内鞘，巨大端细胞见于肌层外鞘的外层。端细胞通过细和粗的端粒（有孔膜）相连。有孔膜使端细胞能够沿着输卵管的整个肌壁建立连接。端细胞建立了一个由不同类型的细胞和结构组成的广泛生物网络，包括上皮细胞、肌肉细胞、肥大细胞、血管、球旁器和神经纤维。我们假设端细胞有助于组织输卵管中不同类型细胞之间的功能协调。
