Chen Lihua, Chi Peilian, Li Xiaoming, Zilioli Samuele, Zhao Junfeng, Zhao Guoxiang, Lin Danhua
a Institute of Developmental Psychology, Beijing Normal University , Beijing , People's Republic of China.
b Department of Psychology, Faculty of Social Sciences , University of Macau , Macau SAR, People's Republic of China.
AIDS Care. 2017 Aug;29(8):1034-1040. doi: 10.1080/09540121.2016.1274015. Epub 2016 Dec 28.
Affect is believed to be one of the most prominent proximal psychological pathway through which more distal psychosocial factors influence physiology and ultimately health. The current study examines the relative contributions of trait affect and state affect to the hypothalamic-pituitary-adrenal axis activity, with particular focus on cortisol slope, in children affected by parental HIV/AIDS. A sample of 645 children (8-15 years old) affected by parental HIV/AIDS in rural China completed a multiple-day naturalistic salivary cortisol protocol. Trait and state affect, demographics, and psychosocial covariates were assessed via self-report. Hierarchical linear modeling was used for estimating the effects of trait affect and state affect on cortisol slope. Confidence intervals for indirect effects were estimated using the Monte Carlo method. Our results indicated that both trait and state negative affect (NA) predicted flatter (less "healthy") diurnal cortisol slopes. Subsequent analyses revealed that children's state NA mediated the effect of their trait NA on diurnal cortisol slope. The same relationships did not emerge for trait and state positive affect. These findings provide a rationale for future interventions that target NA as a modifiable antecedent of compromised health-related endocrine processes among children affected by parental HIV/AIDS.
情感被认为是最显著的近端心理途径之一，通过这一途径，更遥远的社会心理因素会影响生理状况并最终影响健康。本研究考察了特质情感和状态情感对下丘脑-垂体-肾上腺轴活动的相对贡献，特别关注受父母感染艾滋病毒/艾滋病影响的儿童的皮质醇斜率。在中国农村，对645名受父母感染艾滋病毒/艾滋病影响的儿童（8至15岁）进行了一项为期多天的自然唾液皮质醇研究。通过自我报告评估特质和状态情感、人口统计学特征以及社会心理协变量。采用分层线性模型来估计特质情感和状态情感对皮质醇斜率的影响。使用蒙特卡罗方法估计间接效应的置信区间。我们的结果表明，特质和状态消极情感（NA）均预示着更平缓（较“不健康”）的日间皮质醇斜率。后续分析显示，儿童的状态消极情感介导了其特质消极情感对日间皮质醇斜率的影响。特质和状态积极情感并未呈现出同样的关系。这些发现为未来的干预措施提供了理论依据，这些干预措施将消极情感作为受父母感染艾滋病毒/艾滋病影响的儿童健康相关内分泌过程受损的一个可改变的先行因素。
