Singh Inder P, Kumar Sanjay, Gupta Shiv
Department of Natural Products, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab-160 062, India.
Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab-160 062, India.
Med Chem. 2017;13(5):430-438. doi: 10.2174/1573406412666161228112127.
Naphthyridine scaffold is an important pharmacophore in compounds which have shown various biological activities like antiviral, antimicrobial, anticancer, antiinflammatory and analgesic. This scaffold is also reported to exhibit activity against HIV, HCMV, HSV, HPV and HCV. Antiviral activity displayed by many naphthyridine analogs is in nM range. Only few review articles are available in literature which describe about various biological activities of naphthyridines, but there is no comprehensive compilation particularly for antiviral activities.
The objective of this review is to compile the literature on anti-viral activities of naphthyridine analogs.
SciFinder, Google Scholar and PubMed database were searched with keyword "naphthyridine" and the references obtained were further sorted using keywords "antihiv", "antiviral" and "virus", separately. References obtained were considered to review the antiviral literature of naphthyridines.
Literature search using SciFinder database with different keywords gave several references. Only references of antiviral activities of naphthyridine compounds were reviewed. References to in-silico studies alone or on formulation development or on patents were excluded.
This review will be helpful for future researches to design and synthesize naphthyridine analogs with improved antiviral activities.
萘啶骨架是化合物中的一种重要药效基团，这些化合物已显示出多种生物活性，如抗病毒、抗菌、抗癌、抗炎和镇痛。据报道，该骨架还对HIV、HCMV、HSV、HPV和HCV具有活性。许多萘啶类似物显示的抗病毒活性在纳摩尔范围内。文献中仅有少数综述文章描述了萘啶的各种生物活性，但没有特别针对抗病毒活性的全面汇编。
本综述的目的是汇编有关萘啶类似物抗病毒活性的文献。
使用关键词“萘啶”搜索SciFinder、谷歌学术和PubMed数据库，并分别使用关键词“抗HIV”、“抗病毒”和“病毒”对获得的参考文献进行进一步分类。获得的参考文献用于综述萘啶的抗病毒文献。
使用SciFinder数据库并结合不同关键词进行文献检索得到了多篇参考文献。仅对萘啶化合物的抗病毒活性参考文献进行了综述。仅关于计算机模拟研究、制剂开发或专利的参考文献被排除。
本综述将有助于未来的研究设计和合成具有更高抗病毒活性的萘啶类似物。
