Sharif Elham, Rahman Sumaya, Zia Yumna, Rizk Nasser M
Biomedical Sciences Department, College of Health Sciences, Qatar University, Doha, Qatar.
Biomedical Sciences Department, College of Health Sciences, Qatar University, Doha, Qatar; Physiology Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Int J Womens Health. 2016 Dec 16;9:1-10. doi: 10.2147/IJWH.S120027. eCollection 2017.
This was a prospective cross-sectional study in which 126 female students between the ages of 18 and 30 years were evaluated for the frequency of polycystic ovary syndrome (PCOS) through clinical interview, questionnaire, and anthropometric measurements. The diagnostic criteria of the US National Institutes of Health criteria were used. Menstrual irregularities (MI) were identified, and clinical hyperandrogenism was evaluated by self-assessment of hirsutism using modified Ferriman-Gallwey score. Blood analysis was done for measurement of prolactin, thyroid-stimulating hormone, and the androgen hormones. Of all the students, 37 (30.8%) had MI, 38 (31.7%) had clinical hirsutism, 37 (30.8%) had acne, and 76 (63.3%) had a family history of type 2 diabetes. The estimated frequency of PCOS was 18.33% according to the US National Institutes of Health definition. Hormonal analysis demonstrated a significant increase in androgens (total testosterone, dehydroepiandrosterone sulfate, and free testosterone), and a significant decrease in sex hormone-binding globulin in our PCOS group, with a -value <0.05. This study revealed a higher level of the androgen hormones among PCOS subjects with a frequency of PCOS (18.33%) similar to the global estimates of 10%-20%.
这是一项前瞻性横断面研究，对126名年龄在18至30岁之间的女学生通过临床访谈、问卷调查和人体测量评估多囊卵巢综合征（PCOS）的发病频率。采用美国国立卫生研究院的诊断标准。确定月经不规律（MI）情况，并使用改良的费里曼-盖尔韦评分通过自我评估多毛症来评估临床高雄激素血症。进行血液分析以测量催乳素、促甲状腺激素和雄激素。在所有学生中，37人（30.8%）有月经不规律，38人（31.7%）有临床多毛症，37人（30.8%）有痤疮，76人（63.3%）有2型糖尿病家族史。根据美国国立卫生研究院的定义，PCOS的估计发病率为18.33%。激素分析显示，我们的PCOS组中雄激素（总睾酮、硫酸脱氢表雄酮和游离睾酮）显著升高，性激素结合球蛋白显著降低，P值<0.05。本研究显示，PCOS患者的雄激素水平较高，PCOS发病率（18.33%）与全球估计的10%-20%相似。
