Dr RA Margni, Humoral Immunity Studies Institute, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
Gynecol Endocrinol. 2013 Feb;29(2):141-4. doi: 10.3109/09513590.2012.730581. Epub 2012 Nov 2.
To investigate the relationship between the levels of C-reactive protein (CRP), interleukin-6 (IL-6) and IL-1β and the hormonal and metabolic alterations in women with polycystic ovary syndrome (PCO).
Case-control study. CRP, IL-6 and IL-1β were evaluated in combination with obesity, insulin resistance (IR) and hyperandrogenism parameters in 20 patients with PCO. Twenty healthy women were used as the control.
The average CRP values was 5.1 in the cases vs. 0.8 mg/L in the control group (p < 0.0001). The IL-6 average values were 2.77 in the cases vs. 2.70 pg/ml in the control group (p = 0.254). IL-1β levels were found to be within the normal range in all individuals. A positive correlation was found between the CRP values and the IR (p < 0.0001) as well as with the presence of obesity (p < 0.02). No correlation was found between PCR and hyperandrogenemia (p = 0.4) nor between IL-6 values and IR (p = 0.3), or between the levels of this cytokine and the presence of hyperandrogenemia (p = 0.2). A significant correlation was found between IL-6 levels and obesity (p < 0.0001).
The present study demonstrates the presence of a chronic inflammation status in young women with PCO. These parameters are mainly related to obesity and, to a lesser extent, to IR.
探讨 C 反应蛋白（CRP）、白细胞介素-6（IL-6）和白细胞介素-1β（IL-1β）水平与多囊卵巢综合征（PCO）妇女激素和代谢改变的关系。
病例对照研究。在 20 例 PCO 患者中，结合肥胖、胰岛素抵抗（IR）和高雄激素血症参数，评估 CRP、IL-6 和 IL-1β。20 名健康女性作为对照组。
病例组平均 CRP 值为 5.1mg/L，对照组为 0.8mg/L（p<0.0001）。病例组 IL-6 平均水平为 2.77pg/ml，对照组为 2.70pg/ml（p=0.254）。所有个体的 IL-1β 水平均在正常范围内。CRP 值与 IR 呈正相关（p<0.0001），与肥胖（p<0.02）呈正相关。CRP 与高雄激素血症无相关性（p=0.4），IL-6 与 IR 无相关性（p=0.3），也与高雄激素血症的存在无相关性（p=0.2）。IL-6 水平与肥胖显著相关（p<0.0001）。
本研究表明，年轻的 PCO 妇女存在慢性炎症状态。这些参数主要与肥胖有关，其次与 IR 有关。
