阿尔茨海默病患者组源自对重大疾病联盟数据集中认知测试结果的多变量分析。

Alzheimer's disease patient groups derived from a multivariate analysis of cognitive test outcomes in the Coalition Against Major Diseases dataset.

作者信息

Tishchenko Inna, Riveros Carlos, Moscato Pablo

机构信息

Information-Based Medicine Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; School of Electrical Engineering & Computer Science, The University of Newcastle, Callaghan, NSW, Australia; Information-Based Medicine Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; School of Electrical Engineering & Computer Science, The University of Newcastle, Callaghan, NSW, Australia.

Information-Based Medicine Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; CReDITSS Unit, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; Information-Based Medicine Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; CReDITSS Unit, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.

出版信息

Future Sci OA. 2016 Aug 19;2(3):FSO140. doi: 10.4155/fsoa-2016-0041. eCollection 2016 Sep.

DOI:10.4155/fsoa-2016-0041

PMID:28031982

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5137968/

Abstract

AIM

The mini-mental state examination, commonly used to measure cognitive impairment of Alzheimer's disease (AD) patients, consists of five test categories. The final score is calculated as their total sum, implying a loss of information.

MATERIALS & METHODS: In this study, we propose a new multivariate approach to address this issue.

RESULTS

We analyzed the current largest AD-related coalition against major diseases dataset comprising 3717 patients of interest. Our clustering approach revealed five groups of patients associated with distinct characteristics and prognosis. Interestingly, only three cognitive test categories significantly contribute to their determination: registration, attention and recall.

CONCLUSION

The insight that only these categories are critical for AD group determination may help to resolve the patients' educational background issue often discussed in relation to the mini-mental state examination assessment.

摘要