Koçer Belgin, Tezcan Mehmet Engin, Batur Hale Zeynep, Haznedaroğlu Şeminur, Göker Berna, İrkeç Ceyla, Çetinkaya Rümeysa
Department of Neurology Gazi University School of Medicine Ankara Turkey.
Department of Rheumatology Gazi University School of Medicine Ankara Turkey.
Brain Behav. 2016 Oct 13;6(12):e00586. doi: 10.1002/brb3.586. eCollection 2016 Dec.
The aim of the present study was to investigate the prevalence and pattern of cognitive dysfunction observed in primary Sjögren's syndrome (PSS) and to examine the relationships between cognitive abilities, depression, fatigue, and quality of life.
Thirty-two subjects with PSS were compared with 19 healthy controls on comprehensive neuropsychological, depression, fatigue, health state, and daily-life activities tests.
There was low performance in Clock Drawing, COWAT, Paced Auditory Serial Addition Test (PASAT), Colorless Word Reading (Stroop1) and Recognizing Colors (Stroop2) Patterns of STROOP test, SDLT, Auditory-Verbal Learning Test (AVLT), immediate and long-term verbal memory, Benton Judgment of Line Orientation Test (BJLOT), and in all the patterns of RCFT in PSS patients compared to the healthy control group (< .05). It was observed an increased depression frequency and fatigue severity, impairment in health condition, and a decreased quality of life in PSS cases compared to the healthy controls (< .05). All the depression, fatigue severity, and quality of life tests showed a significant positive correlation with each other (< .05). A significant negative correlation between Clock Drawing and SF-36-BP (= .031, = -.382) and SF-36-GH (= .027, = -.392) was observed.
Clock Drawing, PASAT, and AVLT are very useful tests to determine the subclinical and clinical cognitive dysfunction to evaluate attention, information processing speed, executive functions, and short-term and long-term verbal memory in PSS patients. Depression and fatigue may not affect the neuropsychological tests performance.
本研究旨在调查原发性干燥综合征（PSS）中认知功能障碍的患病率及模式，并探讨认知能力、抑郁、疲劳和生活质量之间的关系。
对32例PSS患者与19名健康对照者进行全面的神经心理学、抑郁、疲劳、健康状况及日常生活活动测试。
与健康对照组相比，PSS患者在画钟试验、COWAT、听觉连续加法测验（PASAT）、无色词阅读（Stroop1）和颜色识别（Stroop2）Stroop测试模式、符号数字连线试验（SDLT）、听觉词语学习测验（AVLT）、即刻和长期言语记忆、本顿线方向判断测验（BJLOT）以及雷-卡分类测验（RCFT）的所有模式中的表现均较差（<.05）。与健康对照组相比，观察到PSS患者的抑郁频率增加、疲劳严重程度增加、健康状况受损及生活质量下降（<.05）。所有抑郁、疲劳严重程度及生活质量测试之间均呈显著正相关（<.05）。观察到画钟试验与SF-36身体疼痛（=0.031，=-0.382）和SF-36总体健康（=0.027，=-0.392）之间存在显著负相关。
画钟试验、PASAT和AVLT是确定PSS患者亚临床和临床认知功能障碍以评估注意力、信息处理速度、执行功能以及短期和长期言语记忆的非常有用的测试。抑郁和疲劳可能不会影响神经心理学测试表现。
