Rodrigues Dóra-Neide, Hora João Sergio Ignácio, Salgado Maria Cecília Fonseca, Paes Renata Alves, Vasconcelos Claudia Cristina Ferreira, Landeira-Fernandez J, Alvarenga Regina Maria Papais
Universidade Federal do Estado do Rio de Janeiro, Rio de JaneiroRJ, Brazil.
Serviço de Reumatologia, Hospital Universitário Gaffréé e Guinle, UNIRIO, Rio de JaneiroRJ, Brazil.
Arq Neuropsiquiatr. 2014 Jan;72(1):38-43. doi: 10.1590/0004-282X20130195.
To investigate cognitive deficits in patients with primary Sjögren's syndrome (PSS).
Eighteen patients with PSS, aged between 25 and 61 years, were subjected to a short neuropsychological battery and compared with 18 patients with multiple sclerosis and 18 healthy controls.
The analysis of variance (ANOVA) revealed that the clinical groups had significantly worse performance than the control group on the Rey Auditory Verbal Learning Test 3; (F(2,53) =3.500, p=0.038) and 7 (F(2,53) =5.068, p=0.010). The clinical groups had elevated levels of depression on the Beck Depression Inventory (BDI); (p=0.003). The analysis of the data from the Trail Making Test B-A revealed a significant difference between the clinical and control groups (p=0.023). The analysis of covariance with BDI score as a covariate, did not change the outcome.
Our study revealed cognitive deficits in patients with PSS detectable by a short neuropsychological battery.
研究原发性干燥综合征（PSS）患者的认知缺陷。
对18例年龄在25至61岁之间的PSS患者进行了简短的神经心理测试，并与18例多发性硬化症患者和18名健康对照者进行比较。
方差分析（ANOVA）显示，在雷伊听觉词语学习测验第3项（F(2,53)=3.500，p=0.038）和第7项（F(2,53)=5.068，p=0.010）中，临床组的表现明显比对照组差。临床组在贝克抑郁量表（BDI）上的抑郁水平升高（p=0.003）。对连线测验B-A的数据进行分析发现，临床组和对照组之间存在显著差异（p=0.023）。以BDI分数作为协变量的协方差分析并未改变结果。
我们的研究揭示，通过简短的神经心理测试可检测出PSS患者存在认知缺陷。
