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通过DNA功能化金纳米颗粒的非交联聚集实现细胞色素P450基因多态性的快速裸眼鉴别

Rapid Naked-Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanoparticles.

作者信息

Akiyama Yoshitsugu, Wang Guoqing, Shiraishi Shota, Kanayama Naoki, Takarada Tohru, Maeda Mizuo

机构信息

Bioengineering Laboratory RIKEN2-1 Hirosawa, Wako Saitama 351-0198 Japan; Faculty of Industrial Science and Technology Tokyo University of Science 102-1 Tomino, Oshamambe-cho, Yamakoshi-gun Hokkaido 049-3514 Japan.

Bioengineering Laboratory RIKEN 2-1 Hirosawa, Wako Saitama 351-0198 Japan.

出版信息

ChemistryOpen. 2016 Nov 15;5(6):507. doi: 10.1002/open.201600142. eCollection 2016 Dec.

DOI:10.1002/open.201600142
PMID:28032015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5167336/
Abstract

The front cover artwork is provided by the group of Tohru Takarada at RIKEN (Japan). The image shows a colorimetric single-nucleotide polymorphism (SNP) genotyping method that uses spontaneous aggregation of DNA-modified gold nanoparticles (DNA-AuNPs) for the simple and rapid SNP genotyping of the human cytochrome P450 2C19 monooxygenase gene. For more details, read the full text of the Full Paper at p. 508.

摘要

封面插图由日本理化学研究所（RIKEN）的高田彻（Tohru Takarada）团队提供。该图像展示了一种比色单核苷酸多态性（SNP）基因分型方法，该方法利用DNA修饰的金纳米颗粒（DNA-AuNPs）的自发聚集，对人类细胞色素P450 2C19单加氧酶基因进行简单快速的SNP基因分型。欲了解更多详细信息，请阅读第508页全文。