改良代谢综合征与女性二次癌症：一项病例对照研究。
Modified metabolic syndrome and second cancers in women: A case control study.
作者信息
Ortiz-Mendoza Carlos-Manuel, Pérez-Chávez Ernesto, Fuente-Vera Tania-Angélica De-la
机构信息
Department of Surgery, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
Department of General Surgery, Hospital General Tacuba, ISSSTE, Mexico City, Mexico.
出版信息
South Asian J Cancer. 2016 Oct-Dec;5(4):189-191. doi: 10.4103/2278-330X.195341.
BACKGROUND
According to some studies, the metabolic syndrome causes diverse primary cancers; however, there is no evidence about metabolic syndrome impact on second cancers development in women.
AIM
To find out the implication of the modified metabolic syndrome in women with second cancers.
MATERIALS AND METHODS
This was a case-control study, at a general hospital in Mexico City, in women with second cancers (cases) and age-matched women with only one neoplasm (controls). The analysis comprised: Tumor (s), anthropometric features, and body mass index (BMI); moreover, presence of diabetes mellitus, hypertension, and fasting serum levels of total cholesterol, triglycerides and glucose.
RESULTS
The sample was of nine cases and 27 controls. In cases, the metabolic syndrome (diabetes mellitus or glucose > 99 mg/dL + hypertension or blood pressure ≥ 135/85 mm Hg + triglycerides > 149 mg/dL or BMI ≥ 30 kg/m) was more frequent (odds ratio 20.8, 95% confidence interval: 1.9-227.1).
CONCLUSION
Our results suggest that in women, the modified metabolic syndrome may be a risk factor for second cancers.
背景
根据一些研究，代谢综合征会引发多种原发性癌症；然而，尚无证据表明代谢综合征对女性继发性癌症的发展有影响。
目的
探究改良代谢综合征在患有继发性癌症的女性中的意义。
材料与方法
这是一项病例对照研究，在墨西哥城的一家综合医院进行，研究对象为患有继发性癌症的女性（病例组）和年龄匹配的仅患有一种肿瘤的女性（对照组）。分析内容包括：肿瘤情况、人体测量特征和体重指数（BMI）；此外，还包括糖尿病、高血压的患病情况以及空腹血清总胆固醇、甘油三酯和血糖水平。
结果
样本包括9例病例和27例对照。病例组中，代谢综合征（糖尿病或血糖>99mg/dL + 高血压或血压≥135/85mmHg + 甘油三酯>149mg/dL或BMI≥30kg/m²）更为常见（比值比20.8，95%置信区间：1.9 - 227.1）。
结论
我们的结果表明，在女性中，改良代谢综合征可能是继发性癌症的一个危险因素。
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