O'Toole B I, Burton M J, Rothwell A, Outram S, Dadds M, Catts S V
Brain & Mind Centre, University of Sydney, Sydney, NSW, Australia.
Health Behaviour Sciences, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
Acta Psychiatr Scand. 2017 May;135(5):363-372. doi: 10.1111/acps.12685. Epub 2016 Dec 28.
To assess the association between parental post-traumatic stress disorder (PTSD) and offspring PTSD and its specificity for other disorders in a non-clinical epidemiological cohort of Australian Vietnam veterans, their partners and their sons and daughters.
Veterans were interviewed twice, in 1992-1994 and 2005-2006; partners were interviewed in 2006-2007, and their offspring in 2012-2014. A total of 125 sons and 168 daughters were interviewed from 197 families, 137 of which also included partners who were the mothers of the children. Statistical analysis used multi-level modelling to compute odds ratios and 95% confidence intervals while controlling for clustering effects within families. Parent PTSD diagnoses were examined for associations with offspring trauma exposure, PTSD and other psychiatric diagnoses.
Veteran PTSD increased the risk of PTSD and no other disorder in both sons and daughters; partner PTSD did not. Veteran depression was also a risk factor for sons' PTSD, and alcohol disorder was linked to alcohol dependence in sons and PTSD in daughters, but not when controlling for veteran PTSD.
We conclude that PTSD in a Vietnam veteran father increases the risk specifically for PTSD in his sons and daughters.
在澳大利亚越战退伍军人及其伴侣、子女组成的非临床流行病学队列中，评估父母创伤后应激障碍（PTSD）与子女PTSD之间的关联及其对其他疾病的特异性。
退伍军人在1992 - 1994年和2005 - 2006年接受了两次访谈；伴侣在2006 - 2007年接受访谈，其子女在2012 - 2014年接受访谈。从197个家庭中总共访谈了125名儿子和168名女儿，其中137个家庭还包括作为孩子母亲的伴侣。统计分析采用多层次建模来计算优势比和95%置信区间，同时控制家庭内部的聚类效应。检查父母PTSD诊断与子女创伤暴露、PTSD和其他精神疾病诊断之间的关联。
退伍军人的PTSD增加了儿子和女儿患PTSD的风险，而不增加患其他疾病的风险；伴侣的PTSD则不然。退伍军人的抑郁症也是儿子患PTSD的确危险因素，酒精障碍与儿子的酒精依赖以及女儿的PTSD有关，但在控制退伍军人的PTSD后则不然。
我们得出结论，越战退伍军人父亲的PTSD会增加其子女患PTSD的风险。
