Dehghan Marvast L, Aflatoonian A, Talebi A R, Eley A, Pacey A A
Department of Human Metabolism, Academic Unit of Reproductive and Developmental Medicine, The University of Sheffield, Sheffield, UK.
Research and Clinical Centre for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Andrologia. 2017 Nov;49(9). doi: 10.1111/and.12747. Epub 2016 Dec 29.
The study was performed to investigate the prevalence of Chlamydia trachomatis and Mycoplasma genitalium in a population of infertile couples from Iran and how this relates to tubal factor infertility, pregnancy rate and outcome of pregnancy. Blood, semen and first-void urine samples were obtained from 250 infertile couples and 250 fertile women as a control. Infertile couples were followed up after 24 months to determine diagnosis, referral for assisted conception, any pregnancy and pregnancy outcome. Data were analysed with regard to the results of (i) serological analysis for specific antibodies to C. trachomatis in serum; (ii) the presence of C. trachomatis and M. genitaliumDNA in first-void urine; and (iii) in a semen sample of the male partner. Prevalence of C. trachomatis in our study population was comparable to other studies using similar methods and test specimens. No evidence of M. genitalium infection was found. Detection of C. trachomatis in one partner rarely correlated with infection in the other. The risk of tubal factor infertility and the probability of pregnancy and pregnancy outcome were unrelated to the results of serological tests for C. trachomatis antibodies or the presence of C. trachomatisDNA in first-void urine of both partners and in a semen sample provided by the male.
本研究旨在调查伊朗不孕夫妇人群中沙眼衣原体和生殖支原体的流行情况，以及这与输卵管因素不孕、妊娠率和妊娠结局之间的关系。从250对不孕夫妇和250名有生育能力的女性（作为对照）采集血液、精液和首次晨尿样本。对不孕夫妇进行24个月的随访，以确定诊断、转介辅助受孕、是否妊娠及妊娠结局。根据以下结果进行数据分析：（i）血清中沙眼衣原体特异性抗体的血清学分析结果；（ii）首次晨尿中沙眼衣原体和生殖支原体DNA的存在情况；（iii）男性伴侣精液样本中的情况。本研究人群中沙眼衣原体的流行率与使用类似方法和检测标本的其他研究相当。未发现生殖支原体感染的证据。一方检测到沙眼衣原体很少与另一方感染相关。输卵管因素不孕的风险、妊娠概率和妊娠结局与沙眼衣原体抗体血清学检测结果或双方首次晨尿及男性提供的精液样本中沙眼衣原体DNA的存在情况无关。
