Department of Reproductive Health and Research, World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland.
School of Mathematics and Statistics, University of Melbourne, Melbourne, Australia.
Bull World Health Organ. 2019 Aug 1;97(8):548-562P. doi: 10.2471/BLT.18.228486. Epub 2019 Jun 6.
To generate estimates of the global prevalence and incidence of urogenital infection with chlamydia, gonorrhoea, trichomoniasis and syphilis in women and men, aged 15-49 years, in 2016.
For chlamydia, gonorrhoea and trichomoniasis, we systematically searched for studies conducted between 2009 and 2016 reporting prevalence. We also consulted regional experts. To generate estimates, we used Bayesian meta-analysis. For syphilis, we aggregated the national estimates generated by using Spectrum-STI.
For chlamydia, gonorrhoea and/or trichomoniasis, 130 studies were eligible. For syphilis, the Spectrum-STI database contained 978 data points for the same period. The 2016 global prevalence estimates in women were: chlamydia 3.8% (95% uncertainty interval, UI: 3.3-4.5); gonorrhoea 0.9% (95% UI: 0.7-1.1); trichomoniasis 5.3% (95% UI:4.0-7.2); and syphilis 0.5% (95% UI: 0.4-0.6). In men prevalence estimates were: chlamydia 2.7% (95% UI: 1.9-3.7); gonorrhoea 0.7% (95% UI: 0.5-1.1); trichomoniasis 0.6% (95% UI: 0.4-0.9); and syphilis 0.5% (95% UI: 0.4-0.6). Total estimated incident cases were 376.4 million: 127.2 million (95% UI: 95.1-165.9 million) chlamydia cases; 86.9 million (95% UI: 58.6-123.4 million) gonorrhoea cases; 156.0 million (95% UI: 103.4-231.2 million) trichomoniasis cases; and 6.3 million (95% UI: 5.5-7.1 million) syphilis cases.
Global estimates of prevalence and incidence of these four curable sexually transmitted infections remain high. The study highlights the need to expand data collection efforts at country level and provides an initial baseline for monitoring progress of the 1.
估算 2016 年全球 15-49 岁女性和男性中，淋病奈瑟菌、沙眼衣原体、阴道毛滴虫和梅毒螺旋体引起的泌尿生殖系统感染的流行率和发病率。
对于沙眼衣原体、淋病奈瑟菌和阴道毛滴虫，我们系统地检索了 2009 年至 2016 年期间报告流行率的研究。我们还咨询了区域专家。为了生成估计值，我们使用贝叶斯荟萃分析。对于梅毒，我们汇总了使用 Spectrum-STI 生成的国家估计值。
对于沙眼衣原体、淋病奈瑟菌和/或阴道毛滴虫，有 130 项研究符合条件。对于梅毒，Spectrum-STI 数据库包含了同期 978 个数据点。2016 年全球女性的患病率估计值分别为：沙眼衣原体 3.8%（95%置信区间：3.3-4.5）；淋病奈瑟菌 0.9%（95%置信区间：0.7-1.1）；阴道毛滴虫 5.3%（95%置信区间：4.0-7.2）；梅毒螺旋体 0.5%（95%置信区间：0.4-0.6）。男性的患病率估计值分别为：沙眼衣原体 2.7%（95%置信区间：1.9-3.7）；淋病奈瑟菌 0.7%（95%置信区间：0.5-1.1）；阴道毛滴虫 0.6%（95%置信区间：0.4-0.9）；梅毒螺旋体 0.5%（95%置信区间：0.4-0.6）。估计的总发病例数为 3.764 亿例：沙眼衣原体 1.272 亿例（95%置信区间：9510 万-1.659 亿例）；淋病奈瑟菌 8690 万例（95%置信区间：5860 万-1.234 亿例）；阴道毛滴虫 1.560 亿例（95%置信区间：1.034 亿-2.312 亿例）；梅毒螺旋体 630 万例（95%置信区间：550 万-7.100 万例）。
这四种可治愈的性传播感染的全球流行率和发病率估计值仍然很高。该研究强调了需要在国家一级扩大数据收集工作，并为监测这些疾病的进展提供了初步基线。
