Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran.
Department of Gynecology & Obstetric, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Obstet Gynaecol. 2022 Aug;42(6):2151-2155. doi: 10.1080/01443615.2022.2035328. Epub 2022 May 17.
Infertility is one of the major health problems of patients suffering from bacterial infections. Given the high percentage of infertility, the aim of this study was to investigate the prevalence of , and in fertile and infertile women. In the prospective study, 65 infertile patients and 54 pregnant women referred to Mahdieh Hospital in Tehran were included. After transferring of vaginal swabs to the laboratory, DNA extraction and Polymerase Chain Reaction (PCR) were performed using specific primers. Of the 65 vaginal swab specimens, the prevalence of , and were as 15 (23.1%), 11 (16.9%), 9 (13.8%) and 4 (6.2%), respectively; However, these rate in fertile group was as 6 (11.1%), 3 (5.5%), 5 (9.2%) and 1 (1.8%), respectively. Bacterial infections were higher in infertile group; therefore, these bacterial agents may be associated with female infertility. Timely control and treatment of infections caused by these organisms, together with other factors, can be important in prevention and treatment of the women's infertility and thereby community health.Impact Statement Infertility is one of the most common reproductive health issues in Iran. Female reproductive system is a suitable environment for the growth of many pathogens, which may disrupt any stage of foetal formation, implantation or growth. are the most important microorganisms that have been considered in the infertility. The prevalence of and were higher in infertile women, but there was no statistically significant compared to pregnant women. These results suggest that timely control and treatment of infections caused by these organisms, along with other factors, can be used to prevent and treat women infertility and community health. Based on the results, designing and implementing national control programs to prevent subsequent complications is thought to be necessary. Comprehensive analyses of the overall prevalence of these bacteria, particularly in developing countries (including Iran), may help to carry out such a strategy.
不孕是患有细菌感染的患者面临的主要健康问题之一。鉴于不孕的高比例，本研究旨在调查可育和不孕女性中 、 、 和 的流行情况。在这项前瞻性研究中，将 65 名不孕患者和 54 名前往德黑兰 Mahdieh 医院的孕妇纳入研究。将阴道拭子转移到实验室后，使用特定引物提取 DNA 并进行聚合酶链反应（PCR）。在 65 个阴道拭子标本中， 、 、 和 的流行率分别为 15（23.1%）、11（16.9%）、9（13.8%）和 4（6.2%）；然而，在可育组中这些比率分别为 6（11.1%）、3（5.5%）、5（9.2%）和 1（1.8%）。不孕组中细菌感染率更高；因此，这些细菌可能与女性不孕有关。及时控制和治疗这些病原体引起的感染，加上其他因素，可能对预防和治疗女性不孕以及改善社区健康状况非常重要。影响陈述不孕是伊朗最常见的生殖健康问题之一。女性生殖系统是许多病原体生长的合适环境，这些病原体可能会破坏胎儿形成、着床或生长的任何阶段。 和 是最重要的微生物，已在不孕中进行了研究。不孕妇女中 和 的流行率较高，但与孕妇相比无统计学显著差异。这些结果表明，及时控制和治疗这些病原体引起的感染，以及其他因素，可用于预防和治疗女性不孕和改善社区健康。基于这些结果，设计和实施预防后续并发症的国家控制计划被认为是必要的。对这些细菌的总体流行率进行全面分析，特别是在发展中国家（包括伊朗），可能有助于实施这一策略。
