Mancini S, Ravaioli A, Falcini F, Giuliani O, Corradini R, De Girolamo G, Goldoni C A, Finarelli A C, Naldoni C, Landi P, Sassoli de Bianchi P, Bucchi L
Romagna Cancer Registry, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), IRCCS, Meldola, Forlì, Italy.
Azienda Usl della Romagna, Forlì, Italy.
Eur J Cancer Care (Engl). 2018 Jan;27(1). doi: 10.1111/ecc.12631. Epub 2016 Dec 29.
There is a lack of agreement about which routine invitation strategy should be adopted in colorectal cancer screening. We conducted an observational study to assess the impact of three invitation strategies on participation. Invitation records for the years 2005-2009 were evaluated. There were 2,234,276 invitations from 1,230,683 individuals. Among first invitations, participation associated with direct mailing of the faecal occult blood test kits was slightly lower (relative risk, RR 0.985; 95% confidence interval 0.979-0.990) than that of the reference invitation strategy, that is, the distribution of the test kits by pharmacies. In repeated invitations/previous non-responders, the participation associated with the direct mailing of the test kits was even lower (RR 0.914; 95% confidence interval 0.895-0.933) and this was also the case for the distribution of the test kits by primary care centres (RR 0.983; 95% confidence interval 0.971-0.995). In contrast, in repeated invitations/previous responders, the impact of primary care centres and direct mailing of the test kits was greater than the use of pharmacies, showing only modest RRs: 1.021 (95% confidence interval 1.019-1.023) and 1.029 (95% confidence interval 1.025-1.033) respectively. The faecal occult blood test mailing strategy modestly increased participation in previous responders.
在结直肠癌筛查中，对于应采用哪种常规邀请策略尚无定论。我们进行了一项观察性研究，以评估三种邀请策略对参与率的影响。对2005年至2009年的邀请记录进行了评估。共有来自1,230,683人的2,234,276份邀请。在首次邀请中，与直接邮寄粪便潜血检测试剂盒相关的参与率略低于参考邀请策略，即由药店分发检测试剂盒的参与率（相对风险，RR 0.985；95%置信区间0.979 - 0.990）。在重复邀请/之前未回应者中，与直接邮寄检测试剂盒相关的参与率更低（RR 0.914；95%置信区间0.895 - 0.933），初级保健中心分发检测试剂盒的情况也是如此（RR 0.983；95%置信区间0.971 - 0.995）。相比之下，在重复邀请/之前的回应者中，初级保健中心和直接邮寄检测试剂盒的影响大于通过药店分发，相对风险仅为适度增加：分别为1.021（95%置信区间1.019 - 1.023）和1.029（95%置信区间1.025 - 1.033）。粪便潜血检测邮寄策略适度提高了之前回应者的参与率。
