Yuen Lik Hang, Franzini Raphael M
Department of Medicinal Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, UT, 84113, USA.
Chembiochem. 2017 May 4;18(9):829-836. doi: 10.1002/cbic.201600567. Epub 2017 Jan 25.
DNA-encoded chemical libraries (DECLs) are pools of DNA-tagged small molecules that enable facile screening and identification of bio-macromolecule binders. The successful development of DECLs has led to their increasingly important role in drug development, and screening hits have entered clinical trials. In this review, we summarize the development and currently active research areas of DECLs with a focus on contributions from groups at academic institutes. We further look at opportunities and future directions of DECL research in medicinal chemistry and chemical biology based on the symbiotic relationship between academia and industry. Challenges associated with the application of DECLs in academic drug discovery are further discussed.
DNA编码化学文库（DECLs）是带有DNA标签的小分子集合，能够轻松筛选和鉴定生物大分子结合物。DECLs的成功开发使其在药物开发中发挥着越来越重要的作用，筛选出的活性化合物已进入临床试验阶段。在本综述中，我们总结了DECLs的发展历程和当前活跃的研究领域，重点介绍了学术机构团队所做的贡献。基于学术界与产业界的共生关系，我们进一步探讨了DECL研究在药物化学和化学生物学领域的机遇和未来发展方向。此外，还进一步讨论了DECLs在学术药物发现应用中所面临的挑战。
