Repanos Costa, Mirza Adal H, George Michael, Karkos Petros D
Department of Otolaryngology - Head Neck Surgery, Queen Alexandra Hospital Portsmouth NHS Trust, UK.
Department of Otolaryngology - Head Neck Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Head Neck. 2017 May;39(5):1020-1032. doi: 10.1002/hed.24680. Epub 2016 Dec 29.
The purpose of this study was to present our evaluation of the importance of timing (early vs synchronous vs delayed) in conjunction with transoral laser surgery for head and neck squamous cell carcinoma (HNSCC).
Articles addressing surgical management via transoral laser surgery for HNSCC were included for review.
Twenty-six articles fulfilled our criteria. The overall 5-year disease-specific survival (DSS) was 75.6% (95% confidence interval [CI], 67.3-83.9) and locoregional control was 87.3% (95% CI, 82.3-92.1), respectively. In the synchronous neck dissection group, the mean locoregional control was 89.9% (95% CI, 84.8-95.1) versus 84.5% (95% CI, 56.2-112.7) for the delayed neck dissection group. From studies in which complications were explicitly given, a bleeding rate of 5.3% (95% CI, 3.6-6.9) was established. There were 11.1% of patients who underwent a tracheostomy.
There is no evidence to indicate that timing of neck dissection after transoral laser surgery for HNSCC has any effect on overall survival (OS). © 2016 Wiley Periodicals, Inc. Head Neck, 2016 © 2016 Wiley Periodicals, Inc. Head Neck 39: 1020-1032, 2017.
本研究的目的是阐述我们对于时机（早期、同步或延迟）联合经口激光手术治疗头颈部鳞状细胞癌（HNSCC）重要性的评估。
纳入探讨经口激光手术治疗HNSCC手术管理的文章进行综述。
26篇文章符合我们的标准。总体5年疾病特异性生存率（DSS）为75.6%（95%置信区间[CI]，67.3 - 83.9），局部区域控制率为87.3%（95% CI，82.3 - 92.1）。在同步颈清扫组中，平均局部区域控制率为89.9%（95% CI，84.8 - 95.1），而延迟颈清扫组为84.5%（95% CI，56.2 - 112.7）。在明确给出并发症的研究中，确定出血率为5.3%（95% CI，3.6 - 6.9）。有11.1%的患者接受了气管切开术。
没有证据表明HNSCC经口激光手术后颈清扫的时机对总生存期（OS）有任何影响。© 2016威利期刊公司。《头颈》，2016 © 2016威利期刊公司。《头颈》39: 1020 - 1032，2017。
