School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, P.R. China.
School of Materials Science and Engineering, Jiangsu University, Zhenjiang, P.R. China.
J Sep Sci. 2017 Mar;40(5):1091-1098. doi: 10.1002/jssc.201601180. Epub 2017 Jan 30.
In this work, a molecular dynamics simulation method was introduced to compute the preassembled system of molecular imprinted polymers for sulfamethoxazole monomer. The results revealed that the ratio of sulfamethoxazole as template molecule to 3-aminopropyltriethoxysilane as functional monomer to tetraethylorthosilicate as cross-linker of 10:10:40 led to the most stable template-functional monomer cluster. Based on the result of computational simulation, CdTe@SiO core-shell imprinted polymers, a cadmium telluride quantum dots layer on the surface of aminofunctionalized SiO , were synthesized as the fluorescent sensor. Then, a series of measures were used to characterize the structure and morphology to get optimal sensors. The concentration range was 5.0-30.0 μmol/L between molecular imprinted polymers at CdTe at SiO , and sulfamethoxazole of the fluorescence intensity. To further verify the reliability and accuracy of the fluorescent sensor, the application was successfully by analyzing sulfamethoxazole in pure milk and lake water. The results showed the recoveries were above 96.89% with a relative standard deviation of 1.25-5.45%, and the fluorescence sensor with selective recognition provides an alternative solution for the determination of sulfamethoxazole.
在这项工作中，引入了一种分子动力学模拟方法来计算磺胺甲恶唑单体的分子印迹聚合物预组装体系。结果表明，模板分子磺胺甲恶唑与功能单体 3-氨丙基三乙氧基硅烷和交联剂正硅酸乙酯的比例为 10:10:40 时，模板-功能单体簇最稳定。基于计算模拟的结果，合成了 CdTe@SiO 核壳印迹聚合物，即在氨基功能化的 SiO 表面上有一层碲化镉量子点，作为荧光传感器。然后，采用一系列措施对结构和形态进行了表征，以得到最佳的传感器。在 CdTe@SiO 上的分子印迹聚合物与荧光强度之间，磺胺甲恶唑的浓度范围为 5.0-30.0 μmol/L。为了进一步验证荧光传感器的可靠性和准确性，成功地应用于分析纯牛奶和湖水。结果表明，回收率在 96.89%以上，相对标准偏差为 1.25-5.45%，具有选择性识别能力的荧光传感器为磺胺甲恶唑的测定提供了一种替代方法。
