Taximaimaiti Reyisha, Abuliken Xiekelai, Maihemuti Muzhapaer, Abudujilile Dilinuer, Abudulimu Haimiti
Seven-year Clinical Medicine of Class 2, year 2011,Xinjiang Medical University, Urumqi, PR China. Email:
Asian Pac J Cancer Prev. 2016 Nov 1;17(11):4959-4963. doi: 10.22034/APJCP.2016.17.11.4959.
Objective:Cervical cancer is one of the major causes of mortality of Uyghur women in Xinjiang, China. Although increased expression of orexin receptor (OxR), known to be strongly expressed in human placenta, has a proven relation to some cancers , there have been few studies of cervical cancer. Thus, we explored this question by evaluating the expression of orexin receptor as a biomarker for screening early stage of cervical cancer in Uyghur women with highest occurrence rate of cervical cancer in China. Study Design: We used polymerase chain reaction (PCR) and immunohistochemical staining to determine the expression of both Ox1R and Ox2R in cervical cancer and cervicitis biopsies collected from Uyghur women infected with human papilloma virus (HPV)16. The expression rate was compared between cervical cancers of low, intermediate and high differentiation and cervicitis. Results:Although there was no significant difference in the expression rate of Ox1R between groups, Ox2R was significantly overexpressed in cervical cancer patients when compared to the cervicitis group. Ox1R was negative in normal human placenta while Ox2R was positive. Conclusions: While expression of Ox1R had no correlation with invasion or metastatic potential, Ox2R demonstrated elevation in cervical cancer with heterogeneity in groups with different metastatic potential, in the human placenta as well, implying that it might serve as an indicator of invasive capacity along with other indices.
宫颈癌是中国新疆维吾尔族女性死亡的主要原因之一。虽然已知在人胎盘中强烈表达的食欲素受体（OxR）表达增加与某些癌症存在已证实的关联，但关于宫颈癌的研究却很少。因此，我们通过评估食欲素受体的表达，探索其作为中国宫颈癌发病率最高的维吾尔族女性宫颈癌早期筛查生物标志物的问题。研究设计：我们使用聚合酶链反应（PCR）和免疫组织化学染色来确定从感染人乳头瘤病毒（HPV）16的维吾尔族女性收集的宫颈癌和宫颈炎活检组织中Ox1R和Ox2R的表达。比较了低、中、高分化宫颈癌与宫颈炎之间的表达率。结果：虽然各组之间Ox1R的表达率没有显著差异，但与宫颈炎组相比，Ox2R在宫颈癌患者中显著过表达。Ox1R在正常人体胎盘中呈阴性，而Ox2R呈阳性。结论：虽然Ox1R的表达与侵袭或转移潜能无关，但Ox2R在宫颈癌中表现出升高，在具有不同转移潜能的组中以及在人体胎盘中也存在异质性，这意味着它可能与其他指标一起作为侵袭能力的指标。
