Graybill Nicole L, Weissig Volkmar
Department of Pharmaceutical Sciences, Nanomedicine Center of Excellence in Translational Cancer Research, College of Pharmacy-Glendale, Midwestern University, Glendale, AZ, USA.
SAGE Open Med. 2017 Nov 3;5:2050312117735774. doi: 10.1177/2050312117735774. eCollection 2017.
A systematic review was conducted to categorize the types of cancerous tissues that express orexin receptors and also to examine the effect of in vitro administration of orexin A or B to corresponding cell samples. Comprehensive literature analyses of primary experimental studies were performed. The results of the review included an increased frequency of orexin receptor expression in many colon and prostate cancer tissues and an upward trend of pro-apoptotic activity in these aggressive cell types.
进行了一项系统综述，以对表达食欲素受体的癌组织类型进行分类，并研究在体外将食欲素A或B施用于相应细胞样本的效果。对主要实验研究进行了全面的文献分析。综述结果包括许多结肠癌和前列腺癌组织中食欲素受体表达频率增加，以及这些侵袭性细胞类型中促凋亡活性呈上升趋势。
