Materials Science & Engineering Program, ‡Department of Radiology, and §Department of Chemistry & Biochemistry, University of California-San Diego , La Jolla, California 92093, United States.
J Am Chem Soc. 2017 Jan 11;139(1):15-18. doi: 10.1021/jacs.6b08800. Epub 2016 Dec 29.
In this paper, we describe a method for the stabilization of low-boiling point (low-bp) perfluorocarbons (PFCs) at physiological temperatures by an amphiphilic triblock copolymer which can emulsify PFCs and be cross-linked. After UV-induced thiol-ene cross-linking, the core of the PFC emulsion remains in liquid form even at temperatures exceeding their boiling points. Critically, the formulation permits vaporization at rarefactional pressures relevant for clinical ultrasound.
本文描述了一种通过两亲性三嵌段共聚物稳定低沸点全氟碳化合物（PFC）的方法，该共聚物可以乳化 PFC 并进行交联。在紫外光诱导的硫醇-烯点击交联后，即使在超过其沸点的温度下，PFC 乳液的核心仍保持液态。关键的是，该配方允许在与临床超声相关的稀疏压力下蒸发。
