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用于基于液滴的体内应用的非离子型含氟表面活性剂。

Non-Ionic Fluorosurfactants for Droplet-Based in vivo Applications.

作者信息

van de Wouw Heidi L, Yen Shuo-Ting, Valet Manon, Garcia Joseph A, Gomez Carlos O, Vian Antoine, Liu Yucen, Pollock Jennifer, Pospíšil Petr, Campàs Otger, Sletten Ellen M

机构信息

Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive E., Los Angeles, CA 90095, USA.

Present address: School of Chemistry and Biochemistry, Georgia Institute of Technology, 770 State Street N.W., Atlanta, GA, 30332, USA.

出版信息

Angew Chem Int Ed Engl. 2024 Dec 20;63(52):e202404956. doi: 10.1002/anie.202404956. Epub 2024 Nov 9.

DOI:10.1002/anie.202404956
PMID:39340199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11656150/
Abstract

Fluorocarbon oils are uniquely suited for many biomedical applications due to their inert, bioorthogonal properties. In order to interface fluorocarbon oils with biological systems, non-ionic fluorosurfactants are necessary. However, there is a paucity of non-ionic fluorosurfactants with low interfacial tension (IFT) to stabilize fluorocarbon phases in aqueous environments (such as oil-in-water emulsions). We developed non-ionic fluorosurfactants composed of a polyethylene glycol (PEG) segment covalently bonded to a flexible perfluoropolyether (PFPE) segment that confer low IFTs between a fluorocarbon oil (HFE-7700) and water. The synthesis of a panel of surfactants spanning a molecular weight range of 0.64-66 kDa with various hydrophilic-lipophilic balances allowed for identification of minimal IFTs, ranging from 1.4 to 17.8 mN m. The majority of these custom fluorosurfactants display poor solubility in water, allowing their co-introduction with fluorocarbon oils and minimal leaching. We applied the PEGPFPE surfactant for mechanical force measurements in zebrafish, enabling exceptional sensitivity.

摘要

由于其惰性、生物正交特性，氟碳油特别适用于许多生物医学应用。为了使氟碳油与生物系统相连接，非离子型氟表面活性剂是必需的。然而，具有低界面张力（IFT）以在水性环境（如水包油乳液）中稳定氟碳相的非离子型氟表面活性剂却很匮乏。我们开发了由共价连接到柔性全氟聚醚（PFPE）链段的聚乙二醇（PEG）链段组成的非离子型氟表面活性剂，这些表面活性剂能使氟碳油（HFE - 7700）与水之间的界面张力降低。合成了一系列分子量范围为0.64 - 66 kDa且具有不同亲水亲油平衡的表面活性剂，从而确定了最低界面张力范围为1.4至17.8 mN/m。这些定制的氟表面活性剂大多数在水中溶解度较差，这使得它们能够与氟碳油共同引入且浸出量极小。我们将聚乙二醇 - 全氟聚醚表面活性剂应用于斑马鱼的机械力测量，实现了极高的灵敏度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/f0bd75604c1b/ANIE-63-e202404956-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/0dbe264573f7/ANIE-63-e202404956-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/76ecd747dc98/ANIE-63-e202404956-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/df92af080706/ANIE-63-e202404956-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/b831ec130abc/ANIE-63-e202404956-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/ba86837968e7/ANIE-63-e202404956-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/f0bd75604c1b/ANIE-63-e202404956-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/0dbe264573f7/ANIE-63-e202404956-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/76ecd747dc98/ANIE-63-e202404956-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/df92af080706/ANIE-63-e202404956-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/b831ec130abc/ANIE-63-e202404956-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/ba86837968e7/ANIE-63-e202404956-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ab/11656150/f0bd75604c1b/ANIE-63-e202404956-g007.jpg

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