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雄激素诱导的长链非编码RNA POTEF-AS1调节凋亡相关通路以促进前列腺癌细胞的存活。

Androgen-induced lncRNA POTEF-AS1 regulates apoptosis-related pathway to facilitate cell survival in prostate cancer cells.

作者信息

Misawa Aya, Takayama Ken-Ichi, Fujimura Tetsuya, Homma Yukio, Suzuki Yutaka, Inoue Satoshi

机构信息

Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Department of Functional Biogerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

出版信息

Cancer Sci. 2017 Mar;108(3):373-379. doi: 10.1111/cas.13151.

DOI:10.1111/cas.13151
PMID:28032932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5378265/
Abstract

Although long non-coding RNAs (lncRNAs) have been associated with a variety of cancers, the interplay between lncRNAs and androgen receptor signaling in prostate cancer is still unclear. We identified an androgen-dependent lncRNA, POTEF-AS1, whose expression was regulated by androgen receptor in two androgen-dependent cells by using directional RNA sequencing analysis. POTEF-AS1 promoted cell growth, repressed genes related to the Toll-like receptor signaling and apoptosis pathways, and inhibited apoptosis in docetaxel-treated LNCaP cells. These findings suggest that POTEF-AS1 would play a key role in the progression of prostate cancer by repressing Toll-like receptor signaling.

摘要

尽管长链非编码RNA（lncRNAs）已被证实与多种癌症相关，但lncRNAs与前列腺癌中雄激素受体信号传导之间的相互作用仍不清楚。我们通过定向RNA测序分析，在两种雄激素依赖细胞中鉴定出一种雄激素依赖性lncRNA，即POTEF-AS1，其表达受雄激素受体调控。POTEF-AS1促进细胞生长，抑制与Toll样受体信号传导和凋亡途径相关的基因，并抑制多西他赛处理的LNCaP细胞的凋亡。这些发现表明，POTEF-AS1可能通过抑制Toll样受体信号传导在前列腺癌进展中发挥关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fd/5378265/898db70e9c4a/CAS-108-373-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fd/5378265/258598b11d35/CAS-108-373-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fd/5378265/bc7b754cf2f0/CAS-108-373-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fd/5378265/92aec8d140ba/CAS-108-373-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fd/5378265/898db70e9c4a/CAS-108-373-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fd/5378265/258598b11d35/CAS-108-373-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fd/5378265/bc7b754cf2f0/CAS-108-373-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fd/5378265/92aec8d140ba/CAS-108-373-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fd/5378265/898db70e9c4a/CAS-108-373-g004.jpg

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Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention.长链非编码 RNA 在前列腺癌中的分子特征：干预途径和治疗靶点的关注。
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