Takayama Ken-Ichi, Inoue Satoshi
Brief Funct Genomics. 2016 May;15(3):257-65. doi: 10.1093/bfgp/elv057. Epub 2015 Dec 17.
Recent transcriptome studies using next-generation sequencing have detected aberrant changes in the expression of noncoding RNAs (ncRNAs) associated with cancer. For prostate cancer, the expression levels of ncRNAs including microRNAs and long noncoding RNAs are strongly associated with diagnosis, carcinogenesis and tumor growth. Moreover, androgen and its cognate receptor, androgen receptor (AR), regulate various signaling pathways for prostate tumor growth. In addition, progression to lethal castration-resistant prostate cancer (CRPC) is also owing to AR function. Systematic analysis of AR-binding sites and their regulated transcripts revealed that many ncRNAs are widely regulated at the transcriptional level. Thus, recent studies provide new insight into the complicated molecular mechanism of prostate cancer progression. This review focused on the role of various ncRNAs in prostate cancer and the association between their expression and CRPC.
近期利用新一代测序技术开展的转录组研究已检测到与癌症相关的非编码RNA（ncRNA）表达存在异常变化。对于前列腺癌而言，包括微小RNA和长链非编码RNA在内的ncRNA表达水平与诊断、致癌作用及肿瘤生长密切相关。此外，雄激素及其同源受体——雄激素受体（AR）调节前列腺肿瘤生长的各种信号通路。另外，进展为致命性去势抵抗性前列腺癌（CRPC）也归因于AR功能。对AR结合位点及其调控转录本的系统分析表明，许多ncRNA在转录水平受到广泛调控。因此，近期研究为前列腺癌进展的复杂分子机制提供了新见解。本综述聚焦于各种ncRNA在前列腺癌中的作用及其表达与CRPC之间的关联。
