Mozafari Sahand, Rezaienia Mohammad A, Paul Gordon M, Rothman Martin T, Wen Pihua, Korakianitis Theodosios
From the *School of Engineering and Materials Science, Queen Mary University of London, London, United Kingdom; †Department of Cardiology. Barts and the London NHS Trust, London Chest Hospital, London, United Kingdom; and ‡Parks College of Engineering, Aviation and Technology, Saint Louis University, St. Louis, Missouri.
ASAIO J. 2017 Jan/Feb;63(1):53-59. doi: 10.1097/MAT.0000000000000457.
The application of centrifugal pumps as heart assist devices imposes design limitations on the impeller geometry. Geometry and operating parameters will affect the performance and the hemocompatibility of the device. Among all the parameters affecting the hemocompatibility, pressure, rotational speed, blade numbers, angle, and width have significant impact on the blood trauma. These parameters directly (pressure, speed) and indirectly (geometry) affect the efficiency of the pump as well. This study describes the experimental investigation on geometric parameters and their effect on the performance of small centrifugal pumps suitable for Mechanical Circulatory Support (MCS) devices. Experimental and numerical techniques were implemented to analyze the performance of 15 centrifugal impellers with different characteristics. The effect of each parameter on the pump performance and hemolysis was studied by calculating the normalized index of hemolysis (NIH) and the shear stress induced in each pump. The results show five and six blades, 15-35° outlet angle, and the lowest outlet width that meets the required pressure rise are optimum values for an efficient hemocompatible pump.
离心泵作为心脏辅助装置的应用对叶轮几何形状施加了设计限制。几何形状和运行参数会影响该装置的性能和血液相容性。在所有影响血液相容性的参数中，压力、转速、叶片数量、角度和宽度对血液损伤有显著影响。这些参数直接（压力、速度）和间接（几何形状）也会影响泵的效率。本研究描述了对几何参数及其对适用于机械循环支持（MCS）装置的小型离心泵性能影响的实验研究。采用实验和数值技术分析了15个具有不同特性的离心叶轮的性能。通过计算溶血归一化指数（NIH）和每个泵中诱导的剪切应力，研究了每个参数对泵性能和溶血的影响。结果表明，五到六个叶片、15 - 35°的出口角以及满足所需压力升高的最低出口宽度是高效血液相容性泵的最佳值。
