Sadeghi Masoumeh, Gharipour Mojgan, Nezafati Pouya, Shafie Davood, Aghababaei Esmaeil, Sarrafzadegan Nizal
Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. AND Department of Cardiac Surgery, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Acta Med Iran. 2016 Nov;54(11):724-730.
The present study aimed to assess changes in resting and maximum heart rates as primary indicators of cardiac autonomic function in metabolic syndrome (MetS) patients and to determine their value for discriminating MetS from non-MetS. 468 participants were enrolled in this cross-sectional study and assessed according to the updated adult treatment panel III (ATP-III) definition of MetS. Resting and maximum heart rates were recorded following the Bruce protocol during an exercise. A receiver operating characteristic (ROC) curve was used to identify the best cutoff point for discriminating MetS from the non-MetS state. 194 participants (41.5%) were diagnosed as MetS. The mean resting heart rate (RHR) was not statistically different between the two groups (P=0.078). However, the mean maximum heart (MHR) rate was considerably higher in participants with MetS (142.37±14.84 beats per min) compared to the non-MetS group (134.62±21.63 beats per min) (P<0.001). In the MetS group, the MHR was positively correlated with the serum triglyceride level (β=0.185, P=0.033) and was inversely associated with age (β=-0.469, P<0.001). The MHR had a moderate value for discriminating MetS from the non-MetS state (c=0.580, P=0.004) with the optimal cutoff point of 140 beats per min. In MetS patients, the MHR was significantly greater compared to non-MetS subjects and was directly correlated with serum triglyceride levels and inversely with advanced age. Moreover, MHR can be used as a suspicious indicator for identifying MetS.
本研究旨在评估静息心率和最大心率的变化，将其作为代谢综合征（MetS）患者心脏自主神经功能的主要指标，并确定其在区分MetS与非MetS方面的价值。468名参与者纳入了这项横断面研究，并根据更新的成人治疗小组III（ATP-III）对MetS的定义进行评估。运动期间按照布鲁斯方案记录静息心率和最大心率。使用受试者工作特征（ROC）曲线来确定区分MetS与非MetS状态的最佳临界点。194名参与者（41.5%）被诊断为MetS。两组的平均静息心率（RHR）无统计学差异（P=0.078）。然而，与非MetS组（134.62±21.63次/分钟）相比，MetS参与者的平均最大心率（MHR）显著更高（142.37±14.84次/分钟）（P<0.001）。在MetS组中，MHR与血清甘油三酯水平呈正相关（β=0.185，P=0.033），与年龄呈负相关（β=-0.469，P<0.001）。MHR在区分MetS与非MetS状态方面具有中等价值（c=0.580，P=0.004），最佳临界点为140次/分钟。在MetS患者中，MHR显著高于非MetS受试者，且与血清甘油三酯水平直接相关，与高龄呈负相关。此外，MHR可作为识别MetS的可疑指标。
