Bonini S, Adriani E, Bonini S, De Petrillo G, Loggi G G, Adabbo A, Pani M, Balsano F
Andrea Cesalpino Foundation, Institute of Clinica Medica, University La Sapienza, Rome, Italy.
Eur Respir J Suppl. 1989 Jun;6:497s-501s.
The study of the late-phase reaction to allergen challenge has greatly contributed to increasing understanding of the relationship existing between immunoglobulin E (IgE) triggering, allergic inflammation and bronchial hyperreactivity, as well as to changing our concept from "causes" to "triggers" of asthma. This paper reviews personal studies on a model of conjunctival provocation in allergic subjects. These studies represent the first evidence of a late-phase reaction in the human eye and contribute to a better knowledge of the network of cells and mediators involved in allergic inflammation which are responsible for heightened bronchial reactivity in allergic asthma.
对变应原激发的迟发相反应的研究极大地促进了人们对免疫球蛋白E（IgE）触发、过敏性炎症和支气管高反应性之间关系的理解，也促使我们将哮喘的概念从“病因”转变为“触发因素”。本文回顾了关于变应性受试者结膜激发模型的个人研究。这些研究首次证明了人眼存在迟发相反应，并有助于更好地了解参与过敏性炎症的细胞和介质网络，这些细胞和介质是过敏性哮喘中支气管反应性增强的原因。
