Arutyunyan Sergey, Uhde Matthew
1 Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL, USA.
2 Palm Beach Consortium for Graduate Medical Education, JFK Medical Center-North Campus, West Palm Beach, FL, USA.
J Int Assoc Provid AIDS Care. 2017 Mar/Apr;16(2):120-124. doi: 10.1177/2325957416686193. Epub 2016 Dec 30.
The benign lymphoepithelial lesion is a rare and diagnostically challenging entity. Classically, these lesions present as early manifestation of HIV infection and are rarely seen in those on highly active antiretroviral therapy. We describe 2 rare cases of HIV-associated lympho-epithelial lesions of parotid gland in a 37-year-old female and a 47-year-old male receiving antiretroviral therapy. The lesions were characterized with respect to clinical features, as well as histopathology and radiology findings. Fine-needle aspiration cytology revealed benign squamous epithelium and lymphocytes. Sonographic evaluation of the parotid gland demonstrated intraparotid solid hypoechoic nodule. Computed tomography showed cystic and solid masses. These lesions were diagnosed as benign lymphoepithelial lesions in both cases. To our knowledge, this is the first report in the published literature describing newly occurring benign lymphoepithelial lesions in patients on antiretroviral therapy.
良性淋巴上皮病变是一种罕见且诊断具有挑战性的疾病。传统上，这些病变是HIV感染的早期表现，在接受高效抗逆转录病毒治疗的患者中很少见。我们描述了2例罕见的HIV相关腮腺淋巴上皮病变病例，分别为一名37岁女性和一名47岁男性，他们均接受抗逆转录病毒治疗。对这些病变的临床特征、组织病理学及放射学表现进行了描述。细针穿刺细胞学检查显示为良性鳞状上皮和淋巴细胞。腮腺超声检查显示腮腺内实性低回声结节。计算机断层扫描显示有囊性和实性肿块。这两例病变均诊断为良性淋巴上皮病变。据我们所知，这是已发表文献中首次报道抗逆转录病毒治疗患者出现新发良性淋巴上皮病变。
