在大型医疗系统中实施快速基因检测以促进淋病奈瑟菌的靶向环丙沙星治疗。
Implementation of a Rapid Genotypic Assay to Promote Targeted Ciprofloxacin Therapy of Neisseria gonorrhoeae in a Large Health System.
作者信息
Allan-Blitz Lao-Tzu, Humphries Romney M, Hemarajata Peera, Bhatti Ashima, Pandori Mark W, Siedner Mark J, Klausner Jeffrey D
机构信息
David Geffen School of Medicine, University of California Los Angeles, CA, USA.
Department of Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
出版信息
Clin Infect Dis. 2017 May 1;64(9):1268-1270. doi: 10.1093/cid/ciw864.
Abstract
Multidrug-resistant Neisseria gonorrhoeae is a top threat to public health. In November 2015, UCLA Health introduced a rapid gyrase A (gyrA) genotypic assay for prediction of Neisseria gonorrhoeae susceptibility to ciprofloxacin. We found a significant reduction in ceftriaxone use with a concomitant increase in targeted therapy.
摘要
耐多药淋病奈瑟菌是对公共卫生的重大威胁。2015年11月，加州大学洛杉矶分校医疗中心引入了一种快速的gyrase A（gyrA）基因分型检测方法，用于预测淋病奈瑟菌对环丙沙星的敏感性。我们发现头孢曲松的使用量显著减少，同时靶向治疗有所增加。
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