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Statins for primary prevention in people with a 10% 10-year cardiovascular risk: too much medicine too soon?

作者信息

Yerrakalva Dharani, Griffin Simon J

机构信息

Department of Primary Care and Public Health, University of Cambridge, Cambridge.

出版信息

Br J Gen Pract. 2017 Jan;67(654):40-41. doi: 10.3399/bjgp17X688789.

DOI:10.3399/bjgp17X688789
PMID:28034950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5198615/
Abstract
摘要

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Statins for primary prevention in people with a 10% 10-year cardiovascular risk: too much medicine too soon?他汀类药物用于10年心血管疾病风险为10%人群的一级预防:用药过早、用药过多?
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本文引用的文献

1
Impact of statin related media coverage on use of statins: interrupted time series analysis with UK primary care data.他汀类药物相关媒体报道对他汀类药物使用的影响:基于英国初级医疗数据的中断时间序列分析
BMJ. 2016 Jun 28;353:i3283. doi: 10.1136/bmj.i3283.
2
Statin tolerability: In defence of placebo-controlled trials.他汀类药物的耐受性:为安慰剂对照试验辩护。
Eur J Prev Cardiol. 2016 May;23(8):891-6. doi: 10.1177/2047487315602861. Epub 2015 Aug 28.
3
Estimated 10-year cardiovascular mortality seriously underestimates overall cardiovascular risk.估计的10年心血管死亡率严重低估了总体心血管风险。
Heart. 2016 Jan;102(1):63-8. doi: 10.1136/heartjnl-2015-307668. Epub 2015 Aug 10.
4
What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebo-controlled trials to aid individual patient choice.服用他汀类药物的患者中,有症状的副作用真正由药物引起的比例是多少?对随机安慰剂对照试验进行系统评价以帮助个体患者做出选择。
Eur J Prev Cardiol. 2014 Apr;21(4):464-74. doi: 10.1177/2047487314525531. Epub 2014 Mar 12.
5
Exercise-induced myalgia may limit the cardiovascular benefits of statins.运动引起的肌肉疼痛可能会限制他汀类药物的心血管益处。
Cardiovasc Drugs Ther. 2013 Dec;27(6):569-72. doi: 10.1007/s10557-013-6483-8.
6
Statins for the primary prevention of cardiovascular disease.他汀类药物用于心血管疾病的一级预防。
Cochrane Database Syst Rev. 2013 Jan 31;2013(1):CD004816. doi: 10.1002/14651858.CD004816.pub5.
7
The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials.他汀类药物降低 LDL 胆固醇对低血管疾病风险人群的影响:27 项随机试验个体数据的荟萃分析。
Lancet. 2012 Aug 11;380(9841):581-90. doi: 10.1016/S0140-6736(12)60367-5. Epub 2012 May 17.
8
Helping patients decide: ten steps to better risk communication.帮助患者决策:改善风险沟通的十步骤。
J Natl Cancer Inst. 2011 Oct 5;103(19):1436-43. doi: 10.1093/jnci/djr318. Epub 2011 Sep 19.
9
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials.他汀类药物与新发糖尿病风险:随机他汀类药物试验的协作荟萃分析。
Lancet. 2010 Feb 27;375(9716):735-42. doi: 10.1016/S0140-6736(09)61965-6. Epub 2010 Feb 16.
10
Effects of simvastatin 40 mg daily on muscle and liver adverse effects in a 5-year randomized placebo-controlled trial in 20,536 high-risk people.在一项针对20536名高危人群开展的为期5年的随机安慰剂对照试验中,每日服用40毫克辛伐他汀对肌肉和肝脏不良反应的影响。
BMC Clin Pharmacol. 2009 Mar 31;9:6. doi: 10.1186/1472-6904-9-6.