精神分裂症患者的代谢综合征、白细胞总数及分类计数
Metabolic Syndrome, Total and Differential White Blood Cell Counts in Patients with Schizophrenia.
作者信息
Pavlović Marko, Babić Dragan, Rastović Pejana, Babić Romana, Vasilj Marina
机构信息
Department of Psychiatry, University Clinical Hospital Mostar, Kneza Mihaila Viševića Humskog bb, 88000 Mostar, Bosnia and Herzegovina,
出版信息
Psychiatr Danub. 2016 Dec;28 Suppl 2:216-222.
BACKGROUND
Numerous studies suggest existence of association between total white blood cell (WBC) count and metabolic syndrome (MS) in general population. Aim of this study was to determine the value of total and differential WBC counts and their association with MS in patients suffering from schizophrenia.
SUBJECTS AND METHODS
This cross-sectional study included 100 subjects in the study group and 100 healthy subjects in control group. MS diagnosis was made according to ATP III criteria, which was the basis for dividing the study and control group into subgroups with regard to MS diagnosis. From blood samples of all subjects total and differential WBC counts were determined.
RESULTS
Schizophrenic subjects with MS had significantly higher total WBC count, as well as neutrophil and monocyte count, when compared with both control subgroups. Total WBC and neutrophil count correlated positively with glucose concentration and MS prevalence and negatively with HDL concentration.
CONCLUSION
Total WBC and neutrophil count might have an important role in forecasting MS development in patients with schizophrenia.
背景
众多研究表明，普通人群中白细胞（WBC）总数与代谢综合征（MS）之间存在关联。本研究的目的是确定白细胞总数及分类计数在精神分裂症患者中的价值及其与代谢综合征的关联。
对象与方法
这项横断面研究包括100名研究组受试者和100名健康对照组受试者。根据ATP III标准进行代谢综合征诊断，这是将研究组和对照组根据代谢综合征诊断分为亚组的依据。测定所有受试者血样中的白细胞总数及分类计数。
结果
与两个对照组亚组相比，患有代谢综合征的精神分裂症患者的白细胞总数以及中性粒细胞和单核细胞计数显著更高。白细胞总数和中性粒细胞计数与血糖浓度和代谢综合征患病率呈正相关，与高密度脂蛋白浓度呈负相关。
结论
白细胞总数和中性粒细胞计数可能在预测精神分裂症患者代谢综合征的发生中起重要作用。
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