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原发性小儿中脑淋巴瘤:罕见部位的罕见小儿肿瘤报告。

Primary pediatric mid-brain lymphoma: Report of a rare pediatric tumor in a rare location.

作者信息

Benson Rony, Mallick Supriya, Purkait Suvendu, Suri Vaishali, Haresh K P, Gupta Subhash, Sharma Dayanand, Julka Pramod Kumar, Rath Goura Kishore

机构信息

Rony Benson, K P Haresh, Subhash Gupta, Dayanand Sharma, Pramod Kumar Julka, Goura Kishore Rath, Department of Radiotherapy, All India Institute of Medical Sciences, New Delhi 110029, India.

出版信息

World J Clin Cases. 2016 Dec 16;4(12):419-422. doi: 10.12998/wjcc.v4.i12.419.

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare disease in pediatric age group. A thirteen-year-old male child presented with complaints of headache for six months, vomiting and diplopia for three days. Magnetic resonance imaging of the brain showed a single lesion of 1.7 cm × 1.6 cm × 1.6 cm in the mid brain and tectum. He underwent a gross total resection of the tumor. The histopathological evaluation revealed B cell high grade non Hodgkin lymphoma. The patient was treated with High dose methotrexate and cranio spinal radiation. The patient was alive without disease 12 mo after completion of treatment. This case highlights importance of keeping PCNSL as differential in brain stem lesions of pediatric patients also. Radiation and chemotherapy remains the most important treatment for such patients.

摘要

原发性中枢神经系统淋巴瘤(PCNSL)在儿童年龄组中是一种罕见疾病。一名13岁男性儿童主诉头痛6个月,呕吐和复视3天。脑部磁共振成像显示中脑和顶盖有一个1.7厘米×1.6厘米×1.6厘米的单一病灶。他接受了肿瘤的全切除。组织病理学评估显示为B细胞高级别非霍奇金淋巴瘤。该患者接受了大剂量甲氨蝶呤和全脑全脊髓放疗。治疗完成后12个月,患者无病存活。该病例强调了在儿科患者脑干病变中也将PCNSL作为鉴别诊断的重要性。放疗和化疗仍然是这类患者最重要的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e2/5156880/c768828c072d/WJCC-4-419-g001.jpg

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