杀菌/通透性增加蛋白基因多态性与炎症性肠病：五项病例对照研究的荟萃分析
Bactericidal/permeability increasing protein gene polymorphism and inflammatory bowel diseases: meta-analysis of five case-control studies.
作者信息
Fan Lijuan, Fu Guoning, Ding Yuanyuan, Lv Peng, Li Hongyun
机构信息
Department of Gastroenterology, Jining First People's Hospital, No. 6 health Road, Jining, Shandong Province, 272000, China.
出版信息
Int J Colorectal Dis. 2017 Mar;32(3):433-435. doi: 10.1007/s00384-016-2740-1. Epub 2016 Dec 30.
OBJECTIVE
Bactericidal/permeability increasing protein (BPI) gene polymorphisms have been extensively investigated in terms of their associations with inflammatory bowel disease (IBD), with contradictory results. The aim of this meta-analysis was to evaluate associations between BPI gene polymorphisms and the risk of IBD, Crohn's disease (CD), and ulcerative colitis (UC).
METHODS
Eligible studies from PubMed, Embase, and Cochrane library databases were identified.
RESULTS
Ten studies (five CD and five UC) published in five papers were included in this meta-analysis. G645A polymorphism was associated with a decreased risk of UC in allele model, dominant model, and homozygous model.
CONCLUSIONS
Our data suggested that BPI G645A polymorphism was associated with a decreased risk of UC; the BPI G645A polymorphism was not associated with the risk of CD.
目的
杀菌/通透性增加蛋白（BPI）基因多态性与炎症性肠病（IBD）的相关性已得到广泛研究，但结果相互矛盾。本荟萃分析的目的是评估BPI基因多态性与IBD、克罗恩病（CD）和溃疡性结肠炎（UC）风险之间的相关性。
方法
从PubMed、Embase和Cochrane图书馆数据库中筛选符合条件的研究。
结果
本荟萃分析纳入了五篇论文中发表的十项研究（五项CD研究和五项UC研究）。在等位基因模型、显性模型和纯合子模型中，G645A多态性与UC风险降低相关。
结论
我们的数据表明，BPI G645A多态性与UC风险降低相关；BPI G645A多态性与CD风险无关。
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