Hendrickson Barbara A, Gokhale Ranjana, Cho Judy H
Section of Infectious Diseases, Department of Pediatrics and the The Martin Boyer Laboratories, University of Chicago, Chicago, Illinois 60637, USA.
Clin Microbiol Rev. 2002 Jan;15(1):79-94. doi: 10.1128/CMR.15.1.79-94.2002.
The chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are recognized as important causes of gastrointestinal disease in children and adults. In this review we delineate the clinical manifestations and diagnostic features of IBD. In addition, we summarize important recent advances in our understanding of the immune mediators of intestinal inflammation. This information has led to new therapeutic approaches in IBD. Further, we discuss the considerable data that point to the significance of genetic factors in the development of IBD and the genetic loci which have been implicated through genome-wide searches. The commensal bacterial flora also appears to be a critical element, particularly in regards to Crohn's disease, although the precise role of the bacteria in the disease manifestations remains unclear. Current investigations promise to yield fresh insights in these areas.
慢性炎症性肠病(IBD),即克罗恩病和溃疡性结肠炎,被认为是儿童和成人胃肠道疾病的重要病因。在本综述中,我们阐述了IBD的临床表现和诊断特征。此外,我们总结了近期在理解肠道炎症免疫介质方面的重要进展。这些信息催生了IBD的新治疗方法。此外,我们讨论了大量数据,这些数据表明遗传因素在IBD发病中的重要性以及通过全基因组搜索发现的相关基因位点。共生细菌菌群似乎也是一个关键因素,尤其是在克罗恩病方面,尽管细菌在疾病表现中的具体作用仍不清楚。目前的研究有望在这些领域产生新的见解。