Akase E, Alkon D L, Disterhoft J F
Department of Cell Biology and Anatomy, Northwestern University Medical School, Chicago, Illinois 60611.
Behav Neurosci. 1989 Oct;103(5):935-43. doi: 10.1037//0735-7044.103.5.935.
Involvement of hippocampus in short-delay eye blink conditioning was reexamined during conditioned response (CR) consolidation. Rabbits received bilateral hippocampectomy, removal of overlying neocortex, or sham lesions and were trained with tone/puff pairings to early acquisition (consolidation) or well trained (overtraining); retention was tested. Two effects were observed: 1) Rabbits with hippocampal lesions showed less retention in the consolidation experiment than controls. Previous studies may not have found this because initial training was more complete. Overtrained hippocampal rabbits showed more retention, which agrees with this suggestion. 2) Hippocampectomized rabbits showed larger CR amplitudes in the overtraining experiment. The complementary roles of hippocampus in the consolidation process during early learning and in modulating the expression of the amplitude/time course of behavioral conditioned responses after associations are well learned are discussed.
在条件反应（CR）巩固过程中，重新研究了海马体在短延迟眨眼条件反射中的作用。兔子接受双侧海马切除术、切除覆盖的新皮层或假损伤，并通过音调/吹气配对训练至早期习得（巩固）或训练良好（过度训练）；然后测试记忆保持情况。观察到两种效应：1）在巩固实验中，海马体损伤的兔子比对照组的记忆保持能力差。先前的研究可能没有发现这一点，因为最初的训练更完整。过度训练的海马体损伤兔子表现出更好的记忆保持能力，这与该观点一致。2）在过度训练实验中，海马体切除的兔子表现出更大的CR幅度。讨论了海马体在早期学习巩固过程中的互补作用，以及在关联学习良好后调节行为条件反应幅度/时间进程表达方面的作用。
