Ivkovich D, Thompson R F
Department of Psychology and Neuroscience Program, University of Southern California, USA.
Behav Neurosci. 1997 Aug;111(4):727-38. doi: 10.1037//0735-7044.111.4.727.
The possible modulatory role of motor cortex in classical conditioning of the eyeblink response was examined by ablating anterior neocortex in rabbits and training them with an auditory conditioned stimulus (CS) and an airpuff unconditioned stimulus (US) in either a delay (Experiment 1) or a trace (Experiment 2) conditioning paradigm. Topographic measures such as amplitude and onset latency were assessed during conditioning sessions for conditioned responses (CRs) and on separate test days for unconditioned responses (URs) by using a range of US intensities. No lesion effects were observed for learning or performance measures in acquisition or retention of either delay or trace conditioning. During trace conditioning, lesioned rabbits did, however, exhibit a trend toward impairment and demonstrated significantly longer CR latencies. Damage to motor and frontal cortex does not significantly affect eyeblink response performance or learning in either a delay or a trace conditioning paradigm.
通过切除兔的前新皮质，并在延迟（实验1）或痕迹（实验2）条件反射范式中用听觉条件刺激（CS）和气吹非条件刺激（US）对其进行训练，研究了运动皮质在眨眼反应经典条件反射中可能的调节作用。在条件反射训练期间，通过使用一系列US强度，评估了诸如幅度和起始潜伏期等地形测量指标，以观察条件反应（CRs），并在单独的测试日评估非条件反应（URs）。在延迟或痕迹条件反射的习得或保持过程中，未观察到损伤对学习或性能测量指标有影响。然而，在痕迹条件反射期间，受损兔确实表现出损伤趋势，并表现出明显更长的CR潜伏期。在延迟或痕迹条件反射范式中，运动皮质和额叶皮质的损伤均不会显著影响眨眼反应性能或学习。
