Kim J J, Clark R E, Thompson R F
Neurosciences Program, University of Southern California, Los Angeles 90089-2520, USA.
Behav Neurosci. 1995 Apr;109(2):195-203. doi: 10.1037//0735-7044.109.2.195.
New Zealand male rabbits (Oryctolagus cuniculus) were trained on a trace eyeblink conditioning paradigm using a 250-ms tone conditioned stimulus, a 100-ms airpuff unconditioned stimulus, and a 500-ms trace interval. Rabbits received bilateral hippocampal aspirations either 1 day or 1 month after learning. Controls consisted of time-matched sham-operated and neocortical aspirated rabbits. When retested on the trace paradigm, rabbits with hippocampal aspirations 1 day after learning were significantly and substantially impaired in the retention of trace conditioned responses. In contrast, rabbits that received hippocampal aspirations 1 month after training retained trace conditioned responses at a level comparable to that of the controls. Moreover, hippocampectomy had no effect on the retention of delay eyeblink conditioning. Thus, the hippocampus appears to be necessary for the retention of recently acquired, but not remotely acquired, trace conditioned responses.
使用250毫秒的纯音条件刺激、100毫秒的吹气非条件刺激和500毫秒的痕迹间隔，在痕迹眨眼条件反射范式下对新西兰雄性家兔（穴兔）进行训练。家兔在学习后1天或1个月接受双侧海马损毁。对照组包括时间匹配的假手术和新皮质损毁的家兔。当在痕迹范式上重新测试时，学习后1天进行海马损毁的家兔在痕迹条件反应的保持上显著且严重受损。相比之下，训练后1个月接受海马损毁的家兔保持的痕迹条件反应水平与对照组相当。此外，海马切除术对延迟眨眼条件反射的保持没有影响。因此，海马体对于近期获得而非远期获得的痕迹条件反应的保持似乎是必要的。
