Stahl Phillip R, Hoxha Elion, Wiech Thorsten, Schröder Cornelia, Simon Ronald, Stahl Rolf A K
Institute of Pathology, University Medical Center Hamburg-Eppendorf.
lll. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf.
Genes Chromosomes Cancer. 2017 Apr;56(4):314-327. doi: 10.1002/gcc.22440. Epub 2017 Feb 6.
We recently described a case of a Thrombospondin Type-1 Domain containing 7A (THSD7A) associated membranous nephropathy in a female patient who was synchronously suffering from a THSD7A-positive malignancy. We here investigated the role of THSD7A as a new potential tumor antigen by evaluating over 20 000 tissue spots in more than 70 different tumor entities by immunohistochemistry using tissue microarrays. THSD7A expression was highly variable in different neoplasias with differing staining patterns. Both gain and loss of THSD7A expression compared to expression status in non-tumor tissue were linked to tumor-specific markers in the different tumor entities and were of prognostic value. The potential role of THSD7A in tumor development and therapy needs further investigation.
我们最近描述了一例患有含血小板反应蛋白1型结构域7A（THSD7A）相关膜性肾病的女性患者，该患者同时患有THSD7A阳性恶性肿瘤。我们在此通过使用组织微阵列的免疫组织化学方法，评估了70多种不同肿瘤实体中的20000多个组织斑点，以研究THSD7A作为一种新的潜在肿瘤抗原的作用。THSD7A表达在不同肿瘤形成中高度可变，染色模式也不同。与非肿瘤组织中的表达状态相比，THSD7A表达的增加和减少均与不同肿瘤实体中的肿瘤特异性标志物相关，且具有预后价值。THSD7A在肿瘤发展和治疗中的潜在作用需要进一步研究。
