Department of Pathology, Saarland University Medical Center, 66421 Homburg, Germany.
Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, 66421 Homburg, Germany.
Int J Mol Sci. 2024 Jul 4;25(13):7355. doi: 10.3390/ijms25137355.
Lung cancer is the leading cause of cancer-related deaths in the western world. Squamous cell carcinoma is one of the most common histological subtypes of this malignancy. For squamous cell carcinoma of the lung (LSCC), prognostic and predictive markers still are largely missing. In a previous study, we were able to show that the expression of THSD7A shows an association with unfavorable prognostic parameters in prostate cancer. There is also a link to a high expression of FAK. There is incidence that SCARA5 might be the downstream gene of THSD7A. Furthermore, there is evidence that SCARA5 interacts with FAK. We were interested in the role of SCARA5 as a potential biomarker in LSCC. Furthermore, we wanted to know whether SCARA5 expression is linked to THSD7A positivity and to the expression level of FAK. For this reason, we analyzed 101 LSCC tumors by immunohistochemistry. Tissue microarrays were utilized. No significant association was found between SCARA5 expression and overall survival or clinicopathological parameters. There was also no significant association between THSD7A positivity and SCARA5 expression level. Moreover, no significant association was found between FAK expression level and SCARA5 expression level. SCARA5 seems not to play a major role as a biomarker in squamous cell carcinoma of the lung.
肺癌是西方世界癌症相关死亡的主要原因。鳞状细胞癌是这种恶性肿瘤最常见的组织学亚型之一。对于肺鳞状细胞癌（LSCC），预后和预测标志物仍然在很大程度上缺失。在之前的一项研究中，我们能够表明 THSD7A 的表达与前列腺癌中不利的预后参数有关。这也与 FAK 的高表达有关。有迹象表明 SCARA5 可能是 THSD7A 的下游基因。此外，有证据表明 SCARA5 与 FAK 相互作用。我们对 SCARA5 作为 LSCC 潜在生物标志物的作用感兴趣。此外，我们想知道 SCARA5 的表达是否与 THSD7A 阳性和 FAK 的表达水平有关。为此，我们通过免疫组织化学分析了 101 例 LSCC 肿瘤。利用组织微阵列。SCARA5 的表达与总生存期或临床病理参数之间没有显著相关性。THSD7A 阳性与 SCARA5 表达水平之间也没有显著相关性。此外，FAK 表达水平与 SCARA5 表达水平之间也没有显著相关性。SCARA5 似乎在肺鳞状细胞癌中作为生物标志物的作用不大。
