Delaney Kamila, Kasprzycka Paulina, Ciemerych Maria Anna, Zimowska Malgorzata
Faculty of Biology, Department of Cytology, Institute of Zoology, University of Warsaw, 1 Miecznikowa St., 02-096 Warsaw, Poland.
Cell Biol Int. 2017 Jul;41(7):706-715. doi: 10.1002/cbin.10725. Epub 2017 Jan 19.
The injury of adult skeletal muscle initiates series of well-coordinated events that lead to the efficient repair of the damaged tissue. Any disturbances during muscle myolysis or reconstruction may result in the unsuccessful regeneration, characterised by strong inflammatory response and formation of connective tissue, that is, fibrosis. The switch between proper regeneration of skeletal muscle and development of fibrosis is controlled by various factors. Amongst them are those belonging to the transforming growth factor β family. One of the TGF-β family members is TGF-β1, a multifunctional cytokine involved in the regulation of muscle repair via satellite cells activation, connective tissue formation, as well as regulation of the immune response intensity. Here, we present the role of TGF-β1 in myogenic differentiation and muscle repair. The understanding of the mechanisms controlling these processes can contribute to the better understanding of skeletal muscle atrophy and diseases which consequence is fibrosis disrupting muscle function.
成年骨骼肌损伤会引发一系列协调良好的事件，从而实现受损组织的有效修复。肌肉溶解或重建过程中的任何干扰都可能导致再生失败，其特征是强烈的炎症反应和结缔组织形成，即纤维化。骨骼肌正常再生与纤维化发展之间的转换受多种因素控制。其中包括属于转化生长因子β家族的那些因素。转化生长因子β家族成员之一是转化生长因子β1，这是一种多功能细胞因子，通过卫星细胞激活、结缔组织形成以及免疫反应强度调节参与肌肉修复的调控。在此，我们阐述转化生长因子β1在成肌分化和肌肉修复中的作用。对控制这些过程的机制的理解有助于更好地理解骨骼肌萎缩以及那些后果是纤维化破坏肌肉功能的疾病。
