Portera Mary V, Karol Seth E, Smith Colton, Yang Wenjian, Cheng Cheng, Neel Michael D, Pui Ching-Hon, Relling Mary V, Kaste Sue C
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.
Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, Tennessee.
Pediatr Blood Cancer. 2017 Jul;64(7). doi: 10.1002/pbc.26407. Epub 2016 Dec 30.
Osteonecrosis is a debilitating toxicity associated with acute lymphoblastic leukemia (ALL) treatment. A recent report associated interindividual differences in hip anatomy with the development of idiopathic osteonecrosis in adults. To evaluate the impact of hip anatomy on the development of therapy-related osteonecrosis, we retrospectively evaluated the femoral neck-shaft angle, femoral neck offset, and lateral center-edge angle using x-rays of 18 osteonecrosis cases and 46 control children treated for newly diagnosed ALL on a single protocol. Despite adequate statistical power, we found no association between hip anatomy and osteonecrosis. Investigation of other factors contributing to ALL-associated osteonecrosis is warranted.
骨坏死是一种与急性淋巴细胞白血病（ALL）治疗相关的使人衰弱的毒性反应。最近的一份报告指出，成人特发性骨坏死的发生与个体髋关节解剖结构的差异有关。为了评估髋关节解剖结构对治疗相关骨坏死发生的影响，我们回顾性地利用X线对18例骨坏死病例和46例按照单一方案治疗新诊断ALL的对照儿童进行了股骨颈干角、股骨颈偏移和外侧中心边缘角的评估。尽管有足够的统计学效力，但我们发现髋关节解剖结构与骨坏死之间并无关联。因此有必要对导致ALL相关骨坏死的其他因素展开调查。
