Early presentation of osteonecrosis in acute lymphoblastic leukemia: Two children from the Nordic and Baltic cohort.
作者信息
Mogensen Signe Sloth, Harila-Saari Arja, Frandsen Thomas Leth, Lähteenmäki Päivi, Castor Anders, Kohonen Ia, Schmiegelow Kjeld, Mäkitie Outi
机构信息
Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
Department of Pediatric Oncology, Astrid Lindgren Children's Hospital, Karolinska Hospital, Stockholm, Sweden.
出版信息
Pediatr Blood Cancer. 2017 Nov;64(11). doi: 10.1002/pbc.26624. Epub 2017 May 18.
Osteonecrosis (ON) is usually considered treatment related in patients with acute lymphoblastic leukemia (ALL). We report two patients with presentation of ON at the time of ALL diagnosis. Both were females and diagnosed with ALL at age 8 and 14 years. In the latter, some symptoms and radiologically verified ON in both knees were still present after the end of ALL therapy. No pediatric patients have previously been reported with ON presenting before initiation of ALL therapy.
Zotero 插件